| Acronym | Meaning |
 | C&T | Communications & Tracking |
| CADH | Communications And Data Handling |
| CARA | Center For Astrophysical Research In Antarctica |
| CASCA | Canadian Astronomical Society |
| CASSINI | Saturn Orbiter And Titan Probe |
| CATS | Cheap Access To Space |
| CBR | Cosmic Background Radiation |
| CCAFS | Cape Canaveral Air Force Station |
| CCD | Charge-Coupled Device |
| CCDS | Centers For The Commercial Development Of Space |
| CCRS | Canada Centre For Remote Sensing |
| CCSDS | Consultative Committee For Space Data Systems |
| CD-ROM | Compact Disk Read-Only Memory |
| CDA | Command And Data Acquisition |
| CDDT | Countdown Demonstration Test |
| CDM | Cold Dark Matter |
| CDS | Command And Data Subsystem |
| CEA | Center For EUV Astrophysics |
| CELSS | Controlled Ecological Life Support System |
| CERES | Clouds And Earth's Radiant Energy System |
| CETA | Crew And Equipment Translation Aid |
| CFA | Harvard-Smithsonian Center For Astrophysics |
| CFC | ChloroFluoroCarbon |
| CFF | Columbus Free Flyer |
| CFHT | Canada-France-Hawaii Telescope |
| CFPA | Center For Particle Astrophysics (Berkeley) |
| CFRP | Carbon Fibre Reinforced Plastic |
| CG | Center Of Gravity |
| CGF | Crystal Growth Furnace |
| CGRO | Compton Gamma Ray Observatory |
| CHARA | Center For High Angular Resolution Astronomy |
| CIRRIS | Cryogenic InfraRed Radiance Instrument For Shuttle |
| CIS | Commonwealth Of Independent States |
| CIT | Circumstellar Imaging Telescope |
| CITA | Canadian Institute For Theoretical Astrophysics |
| CITE | Cargo Integration Test Equipment |
| CLAES | Cryogenic Limb Array Etalon Spectrometer |
| CM | Command Module |
| CM | Center Of Mass |
| CM | Central Meridian |
| CMB | Cosmic Microwave Background |
| CMBR | Cosmic Microwave Background Radiation |
| CMCC | Central Mission Control Centre |
| CNES | Centre National D'Etude Spatiales |
| CNO | Carbon-Nitrogen-Oxygen |
| CNSR | Comet Nucleus Sample Return |
| COBE | COsmic Background Explorer |
| COMPTEL | COMPton TELescope |
| COMSAT | Communications Satellite (Corporation) |
| COSTAR | Corrective Optics Space Telescope Axial Replacement |
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