| Acronym | Meaning |
 | CPCG | Commercial Protein Crystal Growth |
| CR | Correlation Radiometer |
| CRAF | Comet Rendezvous/Asteroid Flyby |
| CREAM | Cosmic Radiation Effects And Activatiom Monitor |
| CRIM | Commercial Refrigerator Incubator Module |
| CRISTA | Cryogenic Infrared Spectrometer Telescope For Atmosphere |
| CRL | Communication Research Lab |
| CRRES | Combined Release/Radiation Effects Satellite |
| CSA | Canadian Space Agency |
| CSIRO | Commonwealth Scientific And Industrial Research Organization |
| CSM | Command And Service Module |
| CSTC | Consolidated Satellite Test Center |
| CTIO | Cerro Tololo Interamerican Observatory |
| CV | Cataclysmic Variable |
| CXBR | Cosmic X-ray Background Radiation |
| CYSB | Cape York Space Base |
| CYSF | Cape York Space Facility |
| CYSP | Cape York Space Port |
| CZCS | Coastal Zone Color Scanner |
| DAC | Delayed Action Command |
| DACS | DATA Acquisition And Control Subsystem |
| DAO | Dominion Astrophysical Observatory |
| DARA | Deutsche Agentur Fuer Raumfahrtangelegenheiten |
| DARPA | Defense Advanced Research Projects Agency |
| DC | Delta Clipper |
| DCA | Defense Communications Agency |
| DCCS | Dynamic Cell Culture System |
| DCX | Delta Clipper EXperimental |
| DDCU | DC-to-DC Converter Unit |
| DDTE | Design |
| DEC | Declination |
| DESAT | Desaturation |
| DFRC | Dryden Flight Research Center |
| DFRF | Dryden Flight Research Facility |
| DIRBE | Diffuse Infrared Background Experiment |
| DLR | Deutsche Forschungsanstalt Fuer Luft- Und Raumfahrt |
| DM | Dark Matter |
| DMR | Differential Microwave Radiometer |
| DMSP | Defense Meteorological Satellite Program |
| DOD | Department Of Defense |
| DOE | Department Of Energy |
| DOE | Department Of Education |
| DOE | Department Of The Environment |
| DOMSAT | Domestic Satellite |
| DOR | Differenced One-way Range |
| DOT | Department Of Transportation |
| DPM | Drop Physics Module |
| DPSS | DATA Processing Services Subsystem |
| DRAO | Dominion Radio Astrophysical Observatory |
| DRSS | DATA Relay Satellite System |
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