| Acronym | Meaning |
| EUV | Extreme UltraViolet |
| EUVE | Extreme UltraViolet Explorer |
| EVA | Extravehicular Activity |
| FAP | Freedom Attached Payloads |
| FAST | Fast Auroral SnapshoT Explorer |
| FBV | Fuel Bleed Valve |
| FEM | Flight-Engineering Model |
| FFCC | Free-Flyer Control Centre |
| FFT | Fast Fourier Transform |
| FGS | Fine Guidance Sensors |
| FHST | Fixed Head Star Trackers |
| FIR | Far InfraRed |
| FIRAS | Far InfraRed Absolute Spectrophotometer |
| FITS | Flexible Image Transport System |
| FOC | Faint Object Camera |
| FOLD | Federally-Owned LANDSAT Data |
| FOS | Faint Object Spectrograph |
| FPD | Flight Projects Directorate |
| FPM | Fiber Pulling In Microgravity |
| FRC | Flight Research Center |
| FRED | Space Station Freedom |
| FRF | Flight Readiness Firing |
| FRR | Flight-Readiness Review |
| FRSI | Flexible Reusable Surface Insulation |
| FTS | Flight Telerobotic Servicer |
| FUSE | Far Ultraviolet Spectroscopic Explorer |
| FWHM | Full Width At Half Maximum |
| GAS | Get-Away Special |
| GBT | Green Bank Telescope |
| GC | Galactic Center |
| GC | Globular Cluster |
| GCVS | General Catalog Of Variable Stars |
| GDCLS | General Dynamics Commercial Launch Services |
| GDS | Great Dark Spot |
| GEM | Giotto Extended Mission |
| GEM | Graphite Epoxy Motor |
| GEO | Geosynchronous Earth Orbit |
| GEODSS | Ground-based Electro-optical Deep-space Surveillance System |
| GGM | Goskogidromet/Gidromettsentr |
| GHA | Greenwich Hour Angle |
| GHRS | Goddard High Resolution Spectrograph |
| GIF | Graphics Interchange Format |
| GISS | Goddard Institute For Space Studies |
| GLOMR | Global Low-Orbiting Message Relay |
| GMC | Giant Molecular Cloud |
| GMRT | Giant Meter-wave Radio Telescope |
| GMS | Geostationary Meterological Satellite |
| GMT | Greenwich Mean Time |
| GNC | Guidance |
| GOES | Geostationary Orbiting Environmental Satellite |