| Acronym | Meaning |
 | CCSP | Coupled Climate Systems Program |
| CCSP | U.S. Climate Change Science Program |
| CCT | Computer-compatible Tape |
| CCTF | Cylindrical Core Test Facility |
| CCTM | Community Chemistry Transport Model |
| CCTP | Clean Coal Technology Program |
| CCU | CRAY Charging Unit |
| CCU | Cooler Control Unit |
| CD | Compact Disk |
| CD-ROM | Compact Disk-read Only Memory |
| CDA | Command And Data Acquisition |
| CDC | Climate Data Center |
| CDC | Control Data Corporation |
| CDC | Centers For Disease Control |
| CDCL | Contract Document Control List |
| CDCR | Concept Design And Cost Review |
| CDDF | Central Data Distribution Facility |
| CDDIS | Crustal Dynamics Data Information System |
| CDE | Common Desktop Environment |
| CDED | Core Dynamics And The Earth's Dynamo |
| CDF | Common Data Format |
| CDFS II | Cloud Depiction And Forecast System |
| CDH | Colorado Department Of Health |
| CDHF | Central Data Handling Facility |
| CDIAC | Carbon Dioxide Information Analysis Center |
| CDIS | Command And Data Interface Simulator Unit |
| CDMS | Cryospheric Data Management System |
| CDOS | Customer Data And Operations System |
| CDP | Community Data Portal |
| CDR | Circular Depolarization Ratio |
| CDR | Critical Design Review |
| CDRL | Contract Data Requirements List |
| CDS | Computing |
| CDS | Coronal Doppler Spectrometer |
| CDSF | Customer Data Service Facility |
| CDT | Conventional Defense Technology |
| CDW | Critical Design Walk-through |
| CE | Combustion Engineering |
| CEA | Commissariat A |
| D&F | Determination And Findings |
| D-B | Davis-Bacon Act |
| D/A | Digital-to-analogue Conversion |
| D/L | Downlink |
| D/RADEX | Digital Radar Experiment |
| D/RADEX | Digital Radar Experiment |
| DA | Drift Angle |
| DA | Deka |
| DAB | Defense Acquisition Board |
| DAC | Douglas Aircraft Corporation |
| DAC | Director's Advisory Committee |
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