| Acronym | Meaning |
 | DCS | Direct Connect Service |
| DCSL | Distributed CSL |
| DCTN | Defense Commercial Telecommunications Network |
| DCVZ | Denver Convergence Vorticity Zone |
| DCX | Delta Clipper Experimental |
| DD | Dated |
| DD | Demonstration Division |
| DD+ | Domestic Data Plus |
| DDB | Delayed Direct Broadcast |
| DDC | Defense Documentation Center |
| DDD | Wind Direction |
| DDE | Dynamic (or Direct) Data Exchange |
| DDE | Distributed Data Environment |
| DDESB | Department Of Defense Explosives Safety Board |
| DDF | Digital Data Formatter |
| DDHS | Digital Data Handling System |
| DDN | Data Defense Network |
| DDR | Deutsche Demokratische Republik |
| DDS | Domestic Data Service |
| DDS | Data Delivery Services |
| DDS | Doctor Of Dental Science |
| DE | Dynamics Explorer |
| DEA | Drug Enforcement Administration |
| DEAR | Department Of Energy Acquisition Regulation |
| DEBITS | Deposition Of Biogeochemical Important Trace Species |
| DEC | Digital Equipment Corporation |
| DEC | DOE Environmental Checklist |
| DECAFE | Dynamique Et Chimie De L'Atmosphere En Foret Equitoriale |
| DECDOS | DEC's Version Of DOS |
| DECMAIL | An Electronic Mail Facility Provided By DEC |
| DECNET | Digital Equipment Corporation Network |
| DECU | Developmental & Educational Communications Unit |
| DECUS | Digital Equipment Computer Users Society |
| DED | Data Element Directory |
| DELNI | Digital Equipment Local Network Interconnect |
| DEM | Digitized Elevation Models |
| DEM | Digital Elevation Model |
| DEMVAL | Demonstration And Validation |
| DERF | Dynamic Extended Range Forecasting |
| DES | Data Encryption Standard |
| DEST | Directed Energy Science & Technology |
| DETEC | Defense Technology Evaluation Code |
| DEWPOINT | Directed Energy Weapon Power Integration |
| DEWS | Doppler Electronic Weather Sensor |
| DF | Direction Finding |
| DFD | Data Flow Diagram |
| DFDR | Digital Flight Data Recorder |
| DFS | Design And Fabrication Services |
| DFVLR | Deutsche Forschungs-und Versuchanstalt F?r Luft-und Raumfahrt E.V. |
| DFW | Dallas-Fort Worth International Airport |
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