| Acronym | Meaning |
 | DPC | DLESE Program Center |
| DPDC | Data Processing And Distribution Center |
| DPFC | Defense Program Field Council |
| DPG | Dahlgren Proving Ground |
| DPH | Dew-point Hygrometer |
| DPMB | Defense Programs Management Board |
| DPMI | DOS Protected Mode Interface |
| DPS | Data Production Services |
| DPSOL | Du Pont Savannah River Operations Logbook |
| DQ | Director Of Quality |
| DQA | Data Quality Assessment |
| DQM | Data Quality Monitor |
| DR | Discrepancy Report |
| DRA | Defense Research & Applications |
| DRAAG | Design Review And Acceptance Group |
| DRB | Design Review Board |
| DRD&DAA | Environmental Research |
| DRE | Defense Research And Engineering |
| DRGS | Direct Read-out Ground Station |
| DRI | Defense Research Internet |
| DRI | Desert Research Institute |
| DRL | Deliverables Requirement List |
| DRL | Data Requirements List |
| DRM | Design Reference Mission |
| DRMS | Data Record Management System |
| DROT | Direct Read Out Terminal |
| DRP | Design Review Presentation |
| DRPN | Division De Recherche En Precision Numerique |
| DRTS | Data Relay And Tracking Satellite |
| DRY-MAP | Mesoscale Alpine Project |
| DS | Lightning Detection Systems |
| DS-1 | Digital Signal 1 |
| DSA | Directory System Agent |
| DSAA | Defense Security Assistance Agency |
| DSAP | DOE Special Analysis Project |
| DSAT | Distributed System Administration Team |
| DSB | Direct Soundings Broadcast |
| DSDP | Deep Sea Drilling Project |
| DSET | Desert Sunshine Exposure Testing |
| DSI (+/OR MOD) | Ministry Of Defense |
| DSI (+/OR MOD) | Defense Security Installation |
| DSIR | Department Of Scientific & Industrial Research |
| DSL | Distributed Software Libraries |
| DSM | DiMethylSulfide |
| DSM | Demonstration Support Model |
| DSN | Deep Space Network |
| DSN | Defense Switched Network |
| DSRS | Data Storage And Retrieval System |
| DSS | Data Support Section |
| DSSG | Defense Science Study Group |
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