| Acronym | Meaning |
 | ACDF | Advanced Chemical Diagnostics Facility |
| ACDWG | Atmospheric Center Of Data Working Group |
| ACE | Alliance For Clean Energy |
| ACE | American Council On Education |
| ACE | Antarctic Current Experiment |
| ACE | Aerosol Characteristics Experiment |
| ACE | Accelerated Computing Environment |
| ACE-1 | Aerosol Characterization Experiment |
| ACE-ASIA | Asian Pacific Regional Aerosol Characterization Experiment |
| ACEC | American Consulting Engineers Council |
| ACEP | DOC Advisory Committee |
| ACF | Acid Concentrator Feed |
| ACF | Automatic Control Feature |
| ACFM | Actual Cubic Feet Per Minute |
| ACFM | Alternating Current Frequency Modulation |
| ACG | Advanced Computing Group |
| ACGIH | American Conference Of Governmental Industrial Hygienists |
| ACH | Air Changes Per Hour |
| ACHEM | Atmospheric Chemistry Model |
| ACI | Advanced Computing Initiative |
| ACI | Automatic Closure And Interlock |
| ACIS | Automated Chemical Inventory System |
| ACIS | Academic Information Systems |
| ACL | Advanced Computing Laboratory |
| ACL | Alternative Concentration Level/limit |
| ACL | Auxiliary Cooling Loop |
| ACM | Association For Computing Machinery |
| ACM | Advanced Conventional Munitions |
| ACM | Advanced Cruise Missile |
| ACM | Asbestos-containing Material |
| ACME | Airborne Carbone In The Mountains Experiment |
| ACN AWIPS | Communication Network |
| ACNFS | Advisory Committee On Nuclear Facility Safety |
| ACO | Administrative Consent Order |
| ACO | Advance Change Order |
| ACO | Atomic Coordinating Office |
| ACO/UK | ACO/United Kingdom |
| ACOS | Advanced Coronal Observing System |
| ACP | Acoustic Doppler Profilers |
| ACR | Active Cavity Radiometer |
| ACR | Air Conditioner |
| ACRIM | Active Cavity Radiometer Irradiance Monitor |
| ACRIM II | Active Cavity Radiometer Irradiance Monitor |
| ACRS | Advisory Committee |
| ACRT | Aircraft Report |
| ACS | American Chemical Society |
| ACS | Administrative Computing And Systems |
| ACS | Automated Cartridge System |
| ACS | Account Control System |
| ACS | Aldus Color File |
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