| Acronym | Meaning |
 | EFI | Enrico Fermi Institute |
| EFNS | Educational Foundation For Nuclear Science |
| EFT | Enhanced Forecaster Tools |
| EFTA | European Free Trade Association |
| EFTC | European Fluorocarbon Technical Committee |
| EG&G | Inc. |
| EGA | Enhanced Graphics Adapter |
| EGD | Effluent Guidelines Division |
| EGP | Exterior Gateway Protocol |
| EGS | European Geophysical Society |
| EGSE | Electronic Ground Support Equipment |
| EGTF | Electron Gun Test Facility |
| EH | Oxidation Potential |
| EH | Assistant Secretary For Environment |
| EHF | Extremely High Frequency |
| EHF | Extremely High Frequency |
| EI | Electron Ionization |
| EIA | Energy Information Administration |
| EIA | Electronic Industries Association |
| EIB | Environmental Improvement Board |
| EIC | Earth Information System |
| EICC | Emergency Information Control Center |
| EINET | Enterprise Integration Network |
| EIR | Eidgenossisches Institut Fur Reaktorforschung |
| EIS | Environmental Impact Statement |
| EISA | Extended Industry Standard Architecture |
| EISCAT | European Incoherent Scatter Radar System |
| EISPACK | Eigensystem Package Subroutine Computing Facility |
| EL NI-O | The Little Boy |
| ELCHEM | Electrified Clouds As Sources Of NOx |
| ELDO | European Launcher Development Organization |
| ELDOME | Electra Radome |
| ELDORA | Electra Doppler Radar |
| ELDORA/ASTERIX | France-United States Collaborative Development Of The ELDORA |
| ELF | Extremely Low Frequency |
| ELF | Extremely Low Frequency |
| ELGA | (French) Study Of African Squall Lines |
| ELI | Environmental Law Institute |
| ELINT | Electronic Intelligence |
| ELLWAS | Enhanced Low-Level Windshear Alert System |
| ELP | Emission Line Polarimeter |
| ELP | Equipment Loan Program |
| ELSCAM | Electra Scalar Measurements |
| ELVD | Every Launch Vehicle Directorate |
| ELVIS | ELectromagnetic Very Weak Instabilities Saturated |
| ELVIS | Export Licensing Voice Information System |
| EM | Engineering Model |
| EM | Electromagnetic |
| EM | Electromagnetic Conductivity |
| EM | Electronic Mail |
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