| Acronym | Meaning |
 | EOFS | Empirical Orthogonal Functions |
| EOL | Earth Observing Laboratory (formerly ATD) |
| EOL | End Of Life |
| EOLE | The French Program Like GHOST |
| EON | 10 To The 9th Years |
| EOP | Equal Employment Opportunity |
| EOPM | Electro-optic Phase Modulated |
| EOR | Emergency Operations Center |
| EORC | Earth Observation Research Center |
| EORV | Emergency Operating Records Vault |
| EOS | Earth Observing System |
| EOS-A | First NPOP |
| EOSAT | Earth Observation Satellite Company |
| EOSDIS | Earth Observing System Data And Information System |
| EOSIS | EOS Information System |
| EOSP | Earth Observing Scannign Polarimeter |
| EP | Electrical Power |
| EPA | Environmental Protection Agency |
| EPAA | Environmental Programs Assistance Act |
| EPAC | External Program Advisory Committee |
| EPC | Environmental Forecast Center |
| EPC | Emergency Planning Commission |
| EPI | Electronic Position Indicator |
| EPI | Environmental Policy Institute |
| EPIC | Engineering Physics Information Center |
| EPIC | Environmental Photographic Interpretation Center |
| EPICS | Energetic Pion Channel And Spectrometer |
| EPICS | Experimental Physics & Industrial Control System |
| EPL | Electron Prototype Lab |
| EPO | Estuarine Programs Office |
| EPOCH | European Program On Climatology And Natural Hazards |
| EPOCS | Eastern Pacific Ocean Climate Study |
| EPOP | European Polar Orbiting Platform |
| EPR | Electon Paragmagnetic Resonance |
| EPRI | Electric Power Research Institute |
| EPROM | Electronically Programmable Read Only Memory |
| EQS | Equatorial Scatter |
| ER | Electrical Resistivity |
| ERA | Energy Reorganization Act |
| ERA | Engineering Research Associates |
| ERAB | Energy Research Advisory Board |
| ERACF | Environmental Radiation Ambient Monitoring System |
| ERB | Earth Radiation Budget |
| ERBE | Earth Radiation Budget Experiment |
| ERBI | Earth Radiation Budget Instrument |
| ERBS | Earth Radiation Budget Satellite |
| ERC | Equatorial Ring Current |
| ERC | Environmental Research Center |
| ERDA | Energy Research And Development Administration |
| ERDA | Energy Research And Development Administration |
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