| Acronym | Meaning |
 | FB | Funds Budgeted |
| FB | Fleischmann Building |
| FBA | Forecasting By Analogy |
| FBI | Federal Bureau Of Investigation |
| FCA | Functional Configuration Audit |
| FCC | Federal Communications Commission |
| FCCSET | Federal Coordinating Council On Science |
| FCM | Federal Coordinator For Meteorological Services And Supporting Research |
| FCOM | Federal Coordinators Office Of Meteorology |
| FCST | Federal Council For Science And Technology |
| FD | Facility Division |
| FDA | Food And Drug Administration |
| FDC | Fluid Dynamics Conference |
| FDCA | Federal Drug And Cosmetics Act |
| FDDA | Fiber Distributed Data Interface |
| FDDI | Fiber-distributed Data Interface |
| FDF | Flight Dynamics Facility |
| FDM | Full-depth Model |
| FDMA | Frequency Division Multiple Access |
| FDT | Fully Developed Turbulence |
| FE | Front-end |
| FEMA | Federal Emergency Management Agency |
| FEOSH | Federal Employee Occupational Safety And Health |
| FEP | Front End Processor |
| FEPCA | Federal Environmental Pesticides Control Act |
| FEPCA | Federal Environmental Pollution Control Act |
| FERC | Federal Energy Regulatory Commission |
| FERMILAB | FERMI National Acceleration Laboratory |
| FEST | Fronts Experiment Systems Test |
| FET | Field-effect Transistor |
| FEWS | Follow-on Early Warning System |
| FFDCA | Federal Food, Drug, And Cosmetic Act (US) |
| FFP | Firm Fixed Price |
| FFRDCS | Federally Funded Research And Development Centers |
| FFS | Flight Facilities Survey |
| FFT | Fast Fourier Transform |
| FFTF | Fast Flux Test Facility |
| FFTS | Fast-Fourier Transforms |
| FGCMS | Fast GC / MS = Fast Gas Chromatography / Mass Spectrometry |
| FGGE | First GARP Global Experiment |
| FHSA | Federal Hazardous Substances Act |
| FHWA | Federal Highway Administration |
| FIAR | European Aviation Partnership |
| FICA | Federal Insurance Contributions Act |
| FICS | Facility Information And Control System |
| FIFE | First ISLSCP Field Experiment |
| FIFE II | First ISLSCP Field Experiment II |
| FIFOLIB | N/A |
| FIFRA | Federal Insecticide |
| FILOS | Far Infrared Limb Observing Spectrometer |
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