| Acronym | Meaning |
 | FIPS | Federal Information Processing Standard |
| FIRE | First ISLSCP Regional Experiment |
| FIRE | First ISCCP Radiation Experiment |
| FIRE | Fast Imaging Ranicon Experiment |
| FIRE-ACE | First ISCCP International Satellite Cloud Climatology Program |
| FIRS | Fourier Transform Infrared Sounder |
| FIS | Financial Information System |
| FIVRS | Financial Information Variance Reporting System |
| FL | Foothills Laboratory |
| FL1 | First Flight Model |
| FL2 | Second Flight Model |
| FLAGE | Flexible Lightweight Agile Guided Experiment |
| FLAT | Full Look At Turbulent Kinetic Energy |
| FLD | First Level Destination |
| FLETC | Federal Law Enforcement Training Center |
| FLIP | Floating Instrument Platform |
| FLMPA | Federal Land Management Policy Act |
| FLOP | Floating Point Operations |
| FLOPS | Floating Point Operations Per Second |
| FLOWS | FAA/Lincoln Laboratory Operational Weather Studies |
| FLP | Relocating Floating Point Interpreter |
| FLSA | Fair Labor Standards Act |
| FLTOP | Federal Lease To Ownership Program |
| FLUIDS | MELPROG Subcode |
| FM | Frequency Modulation |
| FMECA | Failure Modes Effects And Critical Analysis |
| FMFIA | Federal Managers Financial Integrity Act |
| FMIT | Fusion Materials Irradiation Test Facility |
| FMLA | Family And Medical Leave Act |
| FMS | French Meteorological Society |
| FNAL | Fermi National Accelerator Laboratory |
| FNC | Federal Networking Council |
| FNOC | Fleet Numerical Operations Center |
| FO | Orbital Frequency |
| FO | Field Office |
| FOB | Free On Board |
| FOB | Facilities Operations Branch |
| FOC | Full Operational Capability |
| FOCAL | Programme Francais Ocean Et Climat Dans D'Atlantique Equatorial |
| FODDAS | Four-Dimensional Data Assimilation Study |
| FOF | Field Observing Faciltilty |
| FOIA | Freedom Of Information Act |
| FOLD | Federally Owned LANDSAT Data |
| FOOTPRINT | Measuring And Modeling The Surface Footprint Of Scalar Fluxes |
| FORD | Flight Operations Requirements Document |
| FORGE | Funds For Overseas Research Grants For Education |
| FORTELL | Not An Acronym |
| FORTRAN | FORmula TRANslation |
| FORTRAN 77 | N/A |
| FOS | Family Of Services |
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