| Acronym | Meaning |
 | HP | Horse Power |
| HPA | High Power Amplifier |
| HPCC | High-performance Computing And Communications |
| HPCS | High-performance Computing Section |
| HPD | Hourly Precipitation Data |
| HPO | High Performance Option |
| HPPI | High Performance Parallel Interface |
| HPS | High Performance Systems |
| HR | Human Resources |
| HRD | Hurricane Research Division |
| HRDI | High Resolution Doppler Imager |
| HRDI | High Resolution Doppler Interferometer |
| HRDL | High-resolution Doppler Lidar |
| HRIR | High-resolution Infrared Radiometer |
| HRIS | High-Resolution Infrared Radiation Sounder |
| HRM | High Rate Multiplexer |
| HRPT | High Resolution Picture Transmission |
| HRS | High-resolution Data Service |
| HRS | Hardwae Requirements Specification |
| HRSO | High Resolution Solar Observatory |
| HRSR | High Resolution Scanning Radiometer |
| HRT | High Rate Tape |
| HRTS | High-resolution Telescope Spectrograph |
| HRV | High-resolution Visible |
| HS | High Speed |
| HSC | High Speed Channel |
| HSCT | High Speed Civil Transport |
| HSI | High-speed Interferometer |
| HSM | Hierarchical Storage Management |
| HSMT | Helical Scan Magnetic Tape |
| HSRP | High Speed Research Program |
| HST | Hubble Space Telescope |
| HTML | Hypertext Mark-up Language |
| HTO | Tritiated Water |
| HTTP | Hypertext Transfer Protocol |
| HVPS | High-volume Precipitation Spectrometer |
| HWCI | Hardware Configuration Item |
| HYPERCHANNNEL | High-speed Communications Link |
| I&T | Integration And Test |
| I&T | Integration And Test |
| I/ O | Input/output |
| I/F | Interface |
| I/O | Input/output |
| I2L | Integrated Injection Logic |
| IA | International Angstrom |
| IAA | International Academy Of Astronautics |
| IAAC | International Antarctic Analysis Center |
| IACOMS | International Advisory Committee On Marine Sciences |
| IAD | Dulles International Airport |
| IADB | Interactive Ancillary Data Base |
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