| Acronym | Meaning |
| IMS | Information Management System |
| IMSL | International Mathematical And Statistical Library |
| IMSP | International Meteorological Service Program |
| IMU | Inertial Measurement Unit |
| INDEX | Indian Ocean Experiment |
| INDOEX | Indian Ocean Experiment |
| INFOTERRA | International Environmental Research And Referral Service Of UNEP |
| INO | Institute For Naval Oceanography |
| INPA | Instituto Nacional De Pesquisas Da Amazonia |
| INPE | Instituto De Pesquisas Espaciais |
| INPUT | N/A |
| INQUA | International Quaternary Research Association Or International Association On Quaternary Research |
| INS | Inertial Navigation System |
| INSAT | Indian National Satellite System |
| INSTAAR | Institute For Arctic And Alpine Research |
| INSTEP | Indonesian Seas Flow Through Experiment |
| INSU | National Institute For Sciences Of The Universe |
| INTELSAT | International Telecommunications Satellite |
| INTERFACE | A Common Boundary Between Software Systems Or Pieces Of Equipment |
| INTERNET | The Collection Of All Interconnected Computer Networks Around The Globe That Use The TCP/IP Protocol |
| INTEX | NASA's Intercontinental Chemical Transport Experiment |
| INU | Inertial Navigation Unit |
| IOC | Intergovernmental Oceanographic Commission |
| IOC | International Ozone Commission |
| IOC | Inception Of Contract |
| IOC | Initial Operating Capability |
| IOP | Intensive Observation Period |
| IOS | Input/Output Subsystem |
| IOS | Interplanetary Scintillation |
| IP | Internet Protocol |
| IPC | Institute Of Paper Chemistry |
| IPC | Instrument Processing Center |
| IPCC | Intergovernmental Panel On Climate Change |
| IPEI | Ionospheric Plasma And Electrodynamics Instrument |
| IPM | Interpersonal Messaging |
| IPMMI | International Photolysis Measurements And Modeling Intercomparison |
| IPMP | Intellectual Property Management Program (UCAR) |
| IPO | International Programs Office |
| IPOC | International Partner Operations Center |
| IPOMS | International Polar-Orbiting Meteorological Satellite Group |
| IPS | Inches Per Second |
| IPT | Integrated Product Teams |
| IPU | Instrument Processor Unit |
| IQSY | International Years Of The Quiet Sun |
| IQSY/EX | International Quiet Years Of The Sun Experiments |
| IR | Infrared |
| IR | Infrared |
| IR&D | Internal Research And Development |
| IR-RAD | Infrared Radiometer |
| IR-RAD | Infrared Radiometer |