| Acronym | Meaning |
 | ISRDB | Incoherent Scatter Radar Data Base |
| ISRIC | International Soil Reference And Information Centre |
| ISRO | Indian Space Research Organization |
| ISS | Integrated Sounding System |
| ISS | Information Support Services |
| ISS | Institute For Space Studies |
| ISSE | Institute For The Study Of Society And The Environment |
| ISSN | International Standard Serial Number |
| ISSS | International Society Of Soil Science |
| IST | Instrument Support Terminal |
| ISTP | International Solar Terrestrial Program |
| ISTS | Institute For Space And Terrestrial Science |
| ISU | Intermediate Storage Unit |
| ISUSS | Integrated Surface And Upper-air Sounding System |
| ISWS | Illinois State Water Survey |
| ISY | International Space Year |
| IT | Information Transport |
| IT | Information Technology |
| ITC | Information Technology Council |
| ITCT | Inter-Continental Transport And Chemical Transformation |
| ITCZ | Intertropical Convergence Zone |
| ITIR | Imaging Thermal Infrared |
| ITIR | Intermediate Thermal Infrared Radiometer |
| ITM | Ionosphere-Thermosphere-Mesosphere |
| ITO | Independent Test Organization |
| ITOS | Improved Tiros Operational Satellite |
| ITPR | Infrared Temperature Profile Radiometer |
| ITR | Institute Technical Reports |
| ITS | Instrument Technical Specification |
| ITS/OT | Institute For Telecommunications |
| ITU | International Telecommunications Union |
| ITVF | Integration |
| ITVM | Integration |
| ITWIS | Integrated Terminal Weather Information System |
| ITWS | Integrated Terminal Weather System |
| IUCR | International Union Of Crystallography |
| IUCRM | Inter Union Commission On Radio Meteorology |
| IUE | International Ultraviolet Explorer |
| IUGG | International Union Of Geodesy And Geophysics |
| IUGS | International Union Of Geological Sciences |
| IUPAB | International Union Of Pure And Applied Biophysics |
| IUPAC | International Union Of Pure And Applied Chemistry |
| IUPAP | International Union Of Pure And Applied Physics |
| IUPS | International Union Of Physiological Sciences |
| IUTAM | International Union Of Theoretical And Applied Mechanics |
| IV&V | Independent Verification And Validation |
| IVVS | Interactive Verification And Visualization System (RTVS) |
| IWC | Ice Water Content |
| IWG | Implementation Working Group |
| IWGDMGC | Interagency Working Group On Data Management For Global Change |
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