| Acronym | Meaning |
 | LIMS | Limb Infrared Monitor Of The Statosphere |
| LINUX | N/A |
| LIRIS | Loral IR Imaging System |
| LIS | Library And Information Systems |
| LIS | Lightning Imaging Sensor |
| LISP | List Processing Language |
| LITE | Lidar In Space Technology Experiment |
| LL | Lincoln Laboratories |
| LLC | Logical Link Control |
| LLNL | Lawrence Livermore National Laboratory(ies) |
| LLP | Lightning Location And Protection |
| LLR | Lunar Laser Ranging |
| LLWAS | Low-Level Wind Shear Alert System |
| LM | Lumen |
| LM | Large Model |
| LME | Layer Management Entity |
| LMER | Land Margin Ecosystems Research |
| LMOS | Lake Michigan Ozone Study |
| LNA | Low-noise Amplifier |
| LNB | N/A |
| LOC | Lines Of Code |
| LOD2 | Lightweight Omega Digital Dropwindsonde |
| LOE | Level Of Effort |
| LOHSS | Local Hardware And Software Systems |
| LOICZ | Land-Ocean Interactions In The Coastal Zone |
| LORAN-C | Long Range (aid To) Navigation-C |
| LOS | Loss Of Signal |
| LOTREX | Working LORAN |
| LOTUS | Lower Thermosphere And Upper Stratosphere |
| LOWL | Low Degree Oscillations Experiment |
| LOX | Liquid Oxygen |
| LPARL | Lockheed Palo Alto Research Laboratory |
| LPATS | Lightning Position And Tracking System |
| LPC | Large Particle Count |
| LPI | Lines Per Inch |
| LPM | Lines Per Minute |
| LRC | Langley Research Center |
| LRE | Latest Revised Estimate |
| LRIR | Limb Radiance Inversion (or Infrared) Radiometer |
| LRT | Low Rate Type |
| LRU | Laser Recording Unit |
| LRU | Line Replaceable Unit |
| LSA | Logistics Support Analysis |
| LSD | Large-scale Dynamics |
| LSFC | Langley Space Flight Center |
| LSI | Large Scale Integration |
| LSI | Lunar Science Institute |
| LSM | Local System Management |
| LSM | Land Surface Model |
| LST | Large Space Telescope |
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