| Acronym | Meaning |
 | AFB | Air Force Base |
| AFB | Atmospheric Fluidized Bed |
| AFC | Automatic Flow Control |
| AFCCN | Air Force Chief Scientist |
| AFCRL | Air Force Cambridge Research Laboratories |
| AFCSA/CC | Commander |
| AFD | Axial Flux Difference |
| AFD | Acid Fractionator Distillate |
| AFEAS | Alternate Fluorocarbon Environmental Acceptability Study |
| AFEL | Advanced Free-electron Laser |
| AFESC | Air Force Engineering & Sciences Center |
| AFGL | Air Force Geophysics Laboratory |
| AFGWC | Air Force Global Weather Central |
| AFI | Atomic Industrial Forum |
| AFIS | Automated Fingerprint Identification System |
| AFM | Atomic Force Microscopy |
| AFNB | US Air Force Scientific Advisory Board |
| AFNE | American For Nuclear Energy |
| AFO | Available For Obligations |
| AFOE | Advanced Fiber Optic Echelle |
| AFOS | Automation Of Field Operations And Services |
| AFOSR | Air Force Office Of Scientific Research |
| AFP | Apple File Protocol |
| AFP | Advanced Flexible Processor |
| AFP | Approved Financial/funding Plan |
| AFP | Approved Funding Program |
| AFPEO/ST | Air Force Programs Executive Officer |
| AFPRO | Air Force Plan Representative Office |
| AFPS | AWIPS Forecast Preparation System |
| AFR | Audit Finding Report |
| AFS | Auxiliary Feedwater System |
| AFSAS | Air Force Director For Strategic Force Analysis |
| AFSC | Air Force Systems Command |
| AFSSO | Air Force Special Security Office |
| AFT | Antifreeze Protein |
| AFTAC | Air Force Technical Applications Center |
| AFV | Alternative Fuel Vehicle |
| AFV | Armored Fighting Vehicle |
| AFW | Auxiliary Feedwater |
| AFWA | Air Force Weather Agency |
| AFWL | Air Force Weapons Laboratory |
| AG | Alternating Gradient |
| AG | Australia Group |
| AGA | Automatic Gas Analyzer |
| AGARD | Advisory Group For Aeronautical Research And Development |
| AGASP | Arctic Gas And Aerosol Sampling Program |
| AGC | Automatic Gain Control |
| AGCM | Atmospheric General Circulation Models |
| AGDATS | Air-Ground Data Telemetry System |
| AGFA | Advanced Gust Front Algorithm |
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