| Acronym | Meaning |
 | MCTEX | Maritime Continent Thunderstorm Experiment |
| MCV | Mesoscale Cyclonic Vortex |
| MD | Master Directory |
| MD | Modernization Division |
| MD FILE | N/A |
| MDC | Modified Direct Costs |
| MDCRS | Meteorological Data Collection And Reporting System |
| MDDS | Maintenance Decision Support System |
| MDI | Michelson Doppler Imager |
| MDM | Multiplexer/demultiplexer |
| MDR | Manually Digitized Radar |
| MDS | Minimum Detectable Signal |
| MECCA | Model Evaluation Consortium For Climate Assessment |
| MECCA | Mesoscale Experiment Center For Control And Analysis |
| MEF | Master E-mail Facility |
| MEFENET | Department Of Energy Network |
| MEGAN | Model Of The Exchange Of Gases Between The Atmosphere And Nature |
| MELTER | Mesosphere/ Lower Thermosphere Explorer |
| MEP | Minority Engineering Program |
| MERIS | Medium Resolution Imaging Spectrometer |
| MERIT | MERIT |
| MERT | Medical Emergency Response Team |
| MESONET | Mesoscale Network |
| METAPPS | Meteorological Applications Task Force |
| METAR | Meteorological Aviation Reports |
| METEOR | Multiple Experiment Transporter Into Earth Orbit And Return |
| METEOSAT | Meteorological Satellite |
| METOBS | N/A |
| METROMEX | Metropolitan Meteorological Experiment |
| MF | Medium Frequency |
| MF | Medium Frequency |
| MFD | Master File Directory |
| MFE | Magnetic Field Explorer |
| MFE | Magnetic Field Experiment |
| MFE/MAGNOLIA | Magnetic Field Explorer/Magnolia Mission |
| MFECC | Magnetic Fusion Energy Computation Center |
| MFEM | Magnetic Field Explorer Mission |
| MFENET | National Magnetic Fusion Energy Network |
| MFLOPS | Megaflops |
| MFM | Standard Hard Drives |
| MFP | Mean Free Path |
| MGA | Meteorological And Geoastrophysical Abstracts |
| MHD | Magnetohydrodynamic |
| MHR | Mile High Radar |
| MHS | Message Handling System |
| MHZ | Megahertz |
| MIB | Management Information Base |
| MICR | Magnetic Ink Character Reader |
| MICRO-SCALE | N/A |
| MICROSOFT | Microsoft Corporation |
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