| Acronym | Meaning |
 | NSTP | National Solar Terrestrial Program |
| NSTS | National Space Transportation System |
| NSWP | National Space Weather Program |
| NT | The Nanotesler (nT) |
| NTCC | Nimbus Technical Control Center |
| NTIS | National Technical Information Service |
| NTISS | National Telecommunications And Information Systems Security |
| NTN | National Telecommunications Network |
| NTP | Network Time Protocol |
| NTRANS | Metacode Translator |
| NTS | Nevada Test Site |
| NTSB | National Transportation Safety Board |
| NTSC | National Television System Committee |
| NTTF | NASA Test And Training Facility |
| NURE | National Uranium Resource Evaluation |
| NUWIG | National Uranium Resource Evaluation |
| NVAP | NASA Water Vapor Project |
| NWP | Numerical Weather Prediction |
| NWRC | National Weather Records Center |
| NWS | National Weather Service |
| NWS | Naval Weather Service |
| NWSC | National Weather Satellite Center |
| NWSFO | National Weather Service Forecast Office |
| NWSOP | National Winter Storms Operations Plan |
| NWSTC | National Weather Service Telecommunications |
| NWSTG | National Weather Service Telecommunications Gateway |
| NYSERNET | New York State Educational And Research Network |
| O AND A | Orbit And Altitude |
| O AND E | Operations And Equipment |
| O AND M | Operations And Maintenance |
| O-LAPS | LAPS Ported To The University Of Oklahoma To Support VORTEX |
| O-O | Object-oriented |
| O/I | Optimal Interpolation |
| OA | Office Automation |
| OAO | Office Of Aircraft Operations |
| OAR | Office Of Aerospace Research |
| OAR | Oceanic And Atmospheric Research |
| OAR | Office Of Atmospheric Research |
| OAS | Organization Of American States |
| OASC | Office Of Advanced Scientific Computing |
| OASIS | Oceanic & Atmospheric Scientific Information System |
| OASM | Operational Analysis Support Model |
| OB | Optical Bench |
| OBAC | Office Of Budget And Control |
| OBC | Onboard Computer |
| OBP | Onboard Processor |
| OBS | Organizational Breakdown Structure |
| OC | Operational Capability |
| OCC | Operations Control Center |
| OCE | Division Of Oceanic Sciences |
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