| Acronym | Meaning |
 | OPLE | Omega Position Location Equipment |
| OPP | Office Of Polar Programs |
| OPPE | Office Of Policy |
| OPS | Onboard Payload Support |
| OPTRAN | Optical Test Transmittance Model |
| OR | Operational Research |
| ORB | Object Request Broker |
| ORCP | Ocean Ridge Crest Processes |
| ORD | Office Of Research And Development |
| ORNL | Oak Ridge National Laboratory |
| ORR | Operations Readiness Review |
| ORSTOM | Institut Francais Pour Le Developpment En Corporation |
| ORU | Orbital Replacement Unit |
| OS | Oceanography Section |
| OS/2 | A Multitasking Operating System Developed By IBM For Its PC-class Computers |
| OSA | Optical Society Of America |
| OSCAR | Oxidant-Scavenging Characteristics Of April Rains |
| OSD | Office Of Systems Development |
| OSDPD | Office Of Space Data Processing And Distribution |
| OSF | Operational Support Facility |
| OSI | Open Systems Interconnection |
| OSIS | Office Of Scientific Information Service |
| OSL | Orbiting Solar Laboratory |
| OSO | Orbiting Solar Observatory |
| OSO | Office Of Systems Operations |
| OSO | Office Of Space Operations |
| OSPF | Open Shortest Path First |
| OSR | Office Of Scientific Research |
| OSS | Observation System Simulation |
| OSS | Office Of Space Station |
| OSSA | Office Of Space Science And Applications |
| OSSE | Observing System Simulation Experiment |
| OST | Office Of Science And Technology |
| OSTIV | Organization Scientifique Et Technique Internationale Du Vol A Voile (conferences) |
| OSTP | Office Of Science And Technology Policy |
| OSTPC | Open Systems Transition Planning Committee |
| OSV | Ocean Station Vessel |
| OT | Optical Techniques Group |
| OTA | Office Of Technology Assessment |
| OTB | Operations Training Branch |
| OTS | Office Of Technical Services |
| OU | University Of Oklahoma |
| OUASS | Omega Upper Atmospheric Sounding Systems |
| OWRR | Office Of Water Resources Research |
| OWWS | Office Of World Weather Systems |
| P/B | Priority Playback |
| P/L-EX | Payload Executive |
| P/L-EX | Payload Executive |
| PA | Position Angle |
| PA | Payload Accommodations |
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