| Acronym | Meaning |
 | SLA | N/A |
| SLAC | Stanford Linear Accelerator Center (or Collider) |
| SLACE | Surface Layer Atmospheric Chemistry Experiment |
| SLAP | Shuttle Laser Altimeter Prototype |
| SLAP | Space Link Access Protocol |
| SLAPS | St. Louis Air Pollution Study |
| SLAR | Side-looking Airborne Radar |
| SLATEC | Sandia-Los Alamos Air Force Weapons Laboratory Technical |
| SLATT | Stratospheric Latitudinal And Temporal Trends (exchange Committee) |
| SLED | Single Large Expensive Disk |
| SLIP | Serial Line Internet Protocol |
| SLP | Sea Level Pressure |
| SLPA | Sea-Level Pressure Anomaly |
| SLR | Satellite Laser Ranging |
| SLT | Semi-Lagrangian Transport |
| SLU | Saint Louis University |
| SLW | Supercooled Liquid Water |
| SMA | Segnalamento Marittimo Ed Aereo |
| SMAGS | SPAN/MASnet Gateway Server |
| SMART-RADAR | The Shared Mobile Atmospheric Research And Teaching Radar |
| SME | Solar Mesosphere Explorer |
| SME | Stratosphere-Mesosphere Explorer Satellite |
| SMETE | National SMETE (Science |
| SMG | Scientific And Management Group |
| SMI | Solar Magnetism Initiative |
| SMIC | Study Of Man's Impact On Climate |
| SMILE | Surface Layer Mixed Experiment |
| SMM | Solar Maximum Mission |
| SMMR | Scanning Multichannel Microwave Radiometer |
| SMOG | N/A |
| SMOW | Standard Mean Ocean Water |
| SMRP | Satellite And Mesometeorology Research Project |
| SMS | Synchronous Meteorological Satellite |
| SMS | Scalable Modeling System |
| SMSC | Shared-Memory Supercomputer Systems |
| SMTP | Simple Mail Transfer Protocol |
| SND | Skewed Normal Distribution |
| SNMP | Simple Network Management Protocol |
| SNR | Signal-to-noise Ratio |
| SOAP | Simple Object Access Protocol |
| SOARS | Significant Opportunities In Atmospheric Research And Science |
| SOCRATES | Simulation Of Chemistry |
| SODAR | Sonic Backscatter Technique For Measuring Wind Profiles |
| SOFAR | Sound |
| SOHO | Solar And Heliosphysical Observatory |
| SOI | Solar Oscillations Imager |
| SOI/MDI | Solar Oscillations Imager/Michelson Doppler Imager |
| SOLAR-B | N/A |
| SOLRAD | NASA Satellite |
| SOLSTICE | Solar/Stellar Irradiance Comparison Experiment |
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