| Acronym | Meaning |
| FPD | Freezing Point Depression |
| FPEIS | Fine Particulate Emissions Information System |
| FPEIS | Final Programmatic Environmental Impact Statement |
| FPGA | Field-programmable Gate Array |
| FPGS | Folylpolyglutamate Synthetasepar |
| FPI | Fourier Path Integral |
| FPIA | Fluorescence Polarization Immunoassay |
| FPKKR | Full-potential Korring-Kohn-Rostoker |
| FPLA | Field-programmable Logic Array |
| FPLC | Fast Protein Liquid Chromatography |
| FPLF | Field-programmable Logic Family |
| FPLH | Free-Phase Liquid Hydrocarbon |
| FPLMTO | Full-potential Linearized Muffin-tin Orbital |
| FPLS | Field-programmable Logic Switch |
| FPLV | Feline Panleukopenia Virus |
| FPM | Fine Particulate Matter |
| FPP | Fertilization Promoting Peptide |
| FPP | Finite Perturbation And Polarization |
| FPPA | Federal Plant Pest Act |
| FPPC | Float Program Planning Committee |
| FPT | Finite Perturbation Theory |
| FPW | Flexural Plate Wave |
| FPXRF | Field Portable X-ray Fluorescence |
| FQHE | Fractional Quantum Hall Effect |
| FQO | Forced Quantum Oscillator Method |
| FQPA | Food Quality Protection Act |
| FR | Federal Register |
| FRAM | Fine Resolution Antarctic Model |
| FRAM | Ferroelectric Random Access Memory |
| FRAP | Fluorescence Recovery After Photobleaching |
| FRAPP | Fluorescence Recovery After Patterned Photobleaching |
| FRAT | Free Radical Assay Technique |
| FRC | Federal Records Center |
| FRC | Free Residual Chlorine |
| FRC | Frozen Core Approxn. |
| FRCA | Fire Retardant Chemicals Association |
| FRCI | Fibrous Refractory Concrete Insulator |
| FRDM | Finite-Range Droplet Model |
| FRDS | Federal Reporting Data System |
| FRED | Flexible Regional Emissions Data System |
| FREDOPS | Fast Response Electrochromic Device On Polymeric Substrate |
| FREEON | Spin-free Orbital |
| FREMSAAS | Frequency Modulated Simultaneous Atomic Absorption Spectrometry |
| FRES | Forward Recoil Emission Spectrometry |
| FRET | Fluorescence Resonance Energy Transfer |
| FRM | Federal Reference Method |
| FRM | Fiber-reinforced Metals |
| FROG | Frequency-resolved Optical Grating |
| FRP | Fiber Reinforced Plastic |
| FRP | Fiberglass Reinforced Plastic |