| Acronym | Meaning |
| SCF MO | Self-consistent Field Molecular Orbital |
| SCF2 | Two-electron Self-consistent Field |
| SCFA | Short Chain Fatty Acid |
| SCFB | Standard Cubic Feet Per Barrel |
| SCFD | Supercritical Fluid Drying |
| SCFM | Standard Cubic Feet Per Minute |
| SCFX-CI | Excited-state Self-consistent Field Configuration Interaction |
| SCG | Slow Crack Growth |
| SCGE | Single Cell Gel Electrophoresis |
| SCGF | Self-consistent Group Function |
| SCGF | Stem Cell Growth Factor |
| SCGP | Shell Coal Gasification Process |
| SCHA | Self-consistent Harmonic Approxn. |
| SCHAZ | Subcritical Heat-affected Zone |
| SCI | Stabilized Criegee Intermediate(s) |
| SCI | Science Citation Index |
| SCI | Single Excitation Configuration Interaction |
| SCI | Spinal Cord Injury |
| SCI | Super Configuration Interaction |
| SCIA | Semiclassical Impact Approxn. (in Ionizing At. And Mol. Collision Calcns.) |
| SCIA | Semiclassical Impulse Approxn. |
| SCIAMACHY | SCanning Imaging Absorption SpectroMeter For Atmospheric CHartographY |
| SCIBM | Semiclassical Infinite-barrier Model |
| SCIC | Single-column Ion Chromatography |
| SCID | Severe Combined Immunodeficiency |
| SCISAS | Size Classifying Isokinetic Sequential Aerosol Sampler |
| SCIT | Standing Committee On Information Technologies |
| SCLC | Small Cell Lung Cancer |
| SCLC | Space Charge Limited Current |
| SCLCP | Side-chain Liquid-crystalline Polymer |
| SCLM | Scanning Confocal Laser Microscopy |
| SCLO | Self-consistent Local Orbital |
| SCLR | Single Configuration Linear Response (theory) |
| SCLS | Spectral Collocation (by) Least Squares |
| SCLS | Surface Core Level Shift |
| SCM | Surface Complexation Model (of Adsorption) |
| SCM | Scanning Capacitance Microscopy |
| SCM | Self-consistent Multipolar (method In Metal Cluster Calcns.) |
| SCM | Shell-correction Method (in Calcns. For Metal Clusters) |
| SCM | Spherical Cellular Model |
| SCM | Streaming Current Monitor (for Coagulation Water Treatment) |
| SCM | Subsurface Chlorophyll Maximum |
| SCMCR | Simulated Countercurrent Moving-bed Chromatographic Reactor |
| SCMFT | Self-consistent Mean-field Theory |
| SCMP | Self-consistent Madelung Potential |
| SCMPS | Spin-corrected Moeller-Plesset Nth-order |
| SCN | Suprachiasmatic Nucleus |
| SCNT | Somatic Cell Nuclear Transfer |
| SCO | Self-consistent Orbital |
| SCOD | Soluble Chemical Oxygen Demand |