| Acronym | Meaning |
| PWB | Printed Wire Board |
| QBE | Query By Example |
| QCELP | QualComm Code Excited Linear Predictive Coding |
| QCIF | Quarter Common Intermediate Format |
| QIC | Quarter-Inch Cartridge |
| QOS | Quality Of Service |
| QSIG | Q (point Of The ISDN Model) Signaling |
| RADIUS | Remote Authentication Dial-In User Service |
| RADSL | Rate-Adaptive Digital Subscriber Line |
| RAID | Redundant Array Of Independent Disks |
| RAID | Redundant Array Of Inexpensive Disks |
| RAM | Random Access Memory |
| RAMDAC | Random Access Memory Digital-to-Analog Converter |
| RARP | Reverse Address Resolution Protocol |
| RAS | Remote Access Services |
| RC4 | RC4 Stream Cipher (Rivest Cipher 4) |
| RDBMS | Relational Database Management System |
| RDF | Resource Description Framework |
| RDRAM | Rambus DRAM |
| RFC | Request For Comments |
| RFI | Radio Frequency Interference |
| RFID | Radio Frequency Identification |
| RFP | Request For Proposal |
| RGB | Red Green Blue |
| RIP | Raster Image Processor |
| RIP | Regulation Of Investigatory Powers Act |
| RISC | Reduced Instruction-Set Computing |
| RJ-11 | Registered Jack-11 |
| RJ-45 | Registered Jack-45 |
| RLL | Run Length Limited |
| RMB | Right Mouse Button |
| RMON | Remote Monitoring |
| RMTP | Reliable Multicast Transport Protocol |
| ROFL | Rolling On Floor, Laughing |
| ROM | Read-Only Memory |
| RPG | Report Program Generator |
| RPG | Role-Playing Game |
| RPM | Revolutions Per Minute |
| RSN | Real Soon Now |
| RSVP | Resource Reservation Setup Protocol |
| RTF | Rich Text Format |
| RTFM | Read The F*cking Manual |
| RTSP | Realtime Streaming Protocol |
| RTT | Round-trip Time |
| S-HTTP | Secure HTTP |
| S/MIME | Secure/MIME |
| SAA | System Application Architecture |
| SAN | Storage Area Network |
| SAP | SAP America, Inc. (SAP AG) |
| SAP | Secondary Audio Program |