| Acronym | Meaning |
 | SAP | Service Advertising Protocol |
| SAS | Serial Attached SCSI |
| SBB | Storage Bridge Bay Working Group |
| SCAM | SCSI Configuration Automatically |
| SCART | Syndicat Des Constructeurs D'Appareils Radior?cepteurs Et T?l?viseurs (Radio And Television Receiver Manufacturer's Association); 21-pin Connector Standard For AV (Audio-visual) Equipment |
| SCSI | Small Computer System Interface |
| SDH | Synchronous Digital Hierarchy |
| SDK | Software Development Kit |
| SDRAM | Synchronous Dynamic RAM |
| SDSL | Symmetric Digital Subscriber Line |
| SET | Secure Electronic Transaction |
| SFF | Small Form-Factor |
| SGI | Silicon Graphics Incorporated |
| SGML | Standard Generalized Markup Language |
| SGRAM | Synchronous Graphic RAM |
| SIG | Special Interest Group |
| SIMD | Single Instruction Multiple Data |
| SIMM | Single In-line Memory Module |
| SIP | Single In-line Package |
| SLDRAM | SyncLink DRAM |
| SLED | Single Large Expensive Disk |
| SLIP | Serial Line Internet Protocol |
| SMART | Self-Monitoring, Analysis And Reporting Technology |
| SMB | Server Message Block |
| SMDS | Switched Multimegabit Data Services |
| SMIF | Stream-based Model Interchange Format |
| SMIL | Synchronized Multimedia Integration Language |
| SMP | Simple Management Protocol |
| SMP | Symmetric Multiprocessing |
| SMS | Systems Management Server |
| SMTP | Simple Mail Transfer Protocol |
| SNA | Systems Network Architecture |
| SNMP | Simple Network Management Protocol |
| SOAP | Simple Object Access Protocol |
| SOC | System-on-a-Chip |
| SOHO | Small Office/Home Office |
| SONET | Synchronous Optical Network |
| SPARC | Scalable Processor Architecture |
| SPE | Superparamagnetic Effect |
| SPEC | Standard Performance Evaluation Corporation |
| SPID | Service Profile (Provider) Identification |
| SPIM | Spam Over Instant Messaging |
| SPX | Sequenced Packet Exchange |
| SQL | Structured Query Language |
| SRAM | Static Random Access Memory |
| SSD | Solid-state Disk |
| SSI | Server-Side Include |
| SSL | Secure Sockets Layer |
| SSSCA | Security Systems Standards And Certification Act |
| ST506/412 | Seagate Technologies 506 And 412 Controller (older Technology) |
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