| Acronym | Meaning |
| UUENCODE | UNIX-to-UNIX Encode |
| VAR | Value-Added Reseller |
| VAX | Virtual Address Extension |
| VBE | Vesa Bios Extension |
| VBNS | Very High-speed Backbone Network Service |
| VCM SDRAM | Virtual-Channel Memory SDRAM |
| VCPI | Virtual Control Program Interface |
| VCSEL | Vertical-Cavity Surface-Emitting Laser |
| VDSL | Very High Bit Rate DSL |
| VDT | Video Display Terminal |
| VERONICA | Very Easy Rodent-Oriented Networkwide Index To Computerized Archives |
| VESA | Video Electronics Standards Association |
| VFAT | Virtual File Allocation Table |
| VFW | Video For Windows |
| VGA | Video Graphics Array (Adapter) |
| VLAN | Virtual LAN |
| VLB | VESA Local Bus (or VL Bus) |
| VME BUS | VersaModule Eurocard Bus |
| VMS | Virtual Memory System |
| VOB | Voice Over Broadband |
| VODSL | Voice Over Digital Subscriber Line |
| VOIP | Voice Over Internet Protocol |
| VPN | Virtual Private Network |
| VR | Virtual Reality |
| VRAM | Video Random Access Memory |
| VRM | Voltage Regulator Module |
| VRML | Virtual Reality Modeling Language |
| VRU | Virus Research Unit |
| VSA | Virtual Storage Architecture |
| VTAM | Virtual Telecommunications Access Method |
| VTC | Virus Test Center |
| W3C | World Wide Web Consortium |
| WAFS | Wide-area File Sharing |
| WAI | Web Accessibility Initiative |
| WAIS | Wide-Area Information Server |
| WAN | Wide Area Network |
| WAP | Wireless Application Protocol |
| WAP | Wireless Access Protocol |
| WATS | Web-based Assessment And Testing Systems |
| WATS | Wide Area Telecommunications System |
| WCS | World Coordinate System |
| WDM | Wavelength Division Multiplexing |
| WEBCGM | Web Computer Graphics Metafile |
| WEBINAR | Web-based Seminar |
| WEP | Wireless Equivalent Privacy |
| WFW | Windows For Workgroups |
| WIAD | Wireless Integrated Access Device |
| WIMP | Windows, Icons, Menus And Pointing Device |
| WINCE | Windows CE |
| WINS | Windows Internet Name Service |