| Acronym | Meaning |
| BSD | Berkeley Software (System) Distribution (Design) |
| BSML | Biosequence Markup Language |
| BSWD | BellSouth Intelligent Wireless Data Network |
| BTW | By The Way |
| CA | Certificate Authority |
| CAD | Computer-Aided Design |
| CAE | Computer-Aided Engineering |
| CASE | Computer-Aided Software Engineering |
| CAV | Constant Angular Velocity |
| CBT | Computer-Based Training |
| CCD | Charge-Coupled Device |
| CCI | Common Content Inspection |
| CCITT | Consultative Committee For International Telephony And Telegraphy |
| CD | Carrier Detect |
| CD-I | Compact Disc-Interactive |
| CD-PROM | Compact Disc-Programmable Read Only Memory |
| CD-R | Compact Disc-Recordable |
| CD-ROM | Compact Disc, Read Only Memory |
| CD-RW | Compact Disc-Rewritable |
| CDC | Cult Of The Dead Cow |
| CDDI | Copper Data Distribution Interface |
| CDF | Channel Definition Format |
| CDFS | Compact Disk File System |
| CDI | Common Data Interface |
| CDIF | CASE Definition Interchange Facility |
| CDMA | Code Division Multiple Access |
| CDPD | Cellular Digital Packet Data |
| CDRAM | Cached Dynamic Random Access Memory |
| CERN | Conseil Europeen Pour Le Recherche Nucleaire |
| CERT | Character Error Rate Testing (European Organization For Nuclear Research) As In, Large Hadron Collider |
| CERT | The CERT Coordination Center |
| CFI | Common Flash Interface |
| CGA | Color Graphics Adapter |
| CGI | Common Gateway Interface |
| CGM | Computer Graphics Metafile |
| CHAP | Challenge Handshake Authentication Protocol |
| CHRP | Common Hardware Reference Platform |
| CIDR | Classless Inter-Domain Routing |
| CIE | Color Model = Commission Internationale De L'Eclairage Color Model |
| CIFF | Camera Image File Format |
| CIR | Committed Information Rate |
| CISC | Complex Instruction-Set Computing |
| CISC | Creative Integrated Solutions Consortium, LLC |
| CIX | Commercial Internet Exchange Association |
| CLEC | Competitive Local Exchange Carriers |
| CLV | Constant Linear Velocity |
| CME | Common Malware Enumeration |
| CMIP | Common Management Information Protocol |
| CML | Chemical Markup Language |
| CMMI | Capability Maturity Model Integration |