| Acronym | Meaning |
 | CMOS | Complementary Metal-Oxide Semiconductor |
| CMS | Color Management System |
| CMS | Content Management System |
| CMTS | Cable Modem Termination System |
| CMYK | Cyan Magenta Yellow Black (Key) |
| CNG | Calling Tone |
| COBOL | Common Business Oriented Language |
| CODASYL | Conference On Data Systems Languages |
| CODEC | Compression/Decompression |
| COM | Component Object Model |
| COMDEX | Communications And Data Processing Exposition |
| CORBA | Common Object Request Broker Architecture |
| CP/M | Control Program For Microprocessors (Control Program/Monitor) |
| CPE | Customer Premises Equipment |
| CPS | Characters Per Second |
| CPU | Central Processing Unit |
| CR | Carriage Return |
| CRAM | Card RAM |
| CRAM | Computational RAM |
| CRC | Cyclic Redundancy Check (Code) |
| CRM | Customer Relationship Management |
| CRT | Cathode-Ray Tube |
| CSDGM | Content Standard For Digital Geospatial Metadata |
| CSMA/CA | Carrier Sense Multiple Access/Collision Avoidance |
| CSMA/CD | Carrier Sense Multiple Access/Collision Detection |
| CSS | Cascading Style Sheets |
| CSTN | Color Supertwist Nematic |
| CSU | Channel Service Unit |
| CSV | Comma-Separated Value / Variable |
| CTI | Computer-Telephony Integration |
| CTP | Community Technical Preview |
| CTR | Click-Through Ratio |
| CUA | Common User Access |
| CWM | Common Warehouse Metadata |
| CWR | Congestion Window Reduced |
| CYA | Cover Your Ass |
| CYBORG | Cybernetic Organism |
| CYMK | Cyan Yellow Magenta Black (Key) |
| DAC | Digital-to-Analog Converter |
| DAFS | Direct Access File System |
| DAFS | Document Attribute Format Specification |
| DAO | Data Access Objects |
| DAO | Disk At Once |
| DASD | Direct Access Storage Device |
| DAT | Digital Audio Tape |
| DB | Database |
| DB2 | Database 2 |
| DBMS | Database Management System |
| DCC | Direct Cable Connection |
| DCE | Data Communications Equipment |
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