| Acronym | Meaning |
| DCF | Design Rule For Camera File Systems |
| DCI | Display Control Interface |
| DDE | Dynamic Data Exchange |
| DDI | Direct Draw Interface |
| DDOS | Distributed Denial-of-Service |
| DDR SDRAM | Double Data Rate-Synchronous DRAM |
| DDS | Digital Data Storage |
| DEBI | DMA Extended Bus Interface |
| DEC | Digital Equipment Corporation |
| DES | Data Encryption Standard |
| DFM | Design For Manufacturing |
| DHCP | Dynamic Host Configuration Protocol |
| DID | Direct Inward Dialing |
| DIF | Data Interchange Format |
| DIF | Directory Interchange Format |
| DIMM | Dual In-Line Memory Module |
| DIN | Deutsches Institut F?r Normung (German Institute For Standardization) |
| DINOR | Divided Bit-line NOR |
| DIP | Dual In-line Package |
| DIVX | Digital Video Express |
| DIZ | Description In ZIP |
| DLC | Data Link Control |
| DLL | Dynamic Link Library |
| DLP | Digital Light Processing |
| DLT | Digital Linear Tape |
| DMA | Direct Memory Access |
| DMCA | Digital Millennium Copyright Act |
| DMG | Data Mining Group |
| DMI | Desktop Management Interface |
| DNS | Domain Name Service (System) |
| DOCSIS/MCNS | Data Over Cable Services And Interface Specifications For Multimedia Cable Network Systems |
| DOM | Document Object Model |
| DOS | Denial-of-Service |
| DOS | Disk Operating System |
| DPI | Dots Per Inch |
| DPMI | DOS Protected Mode Interface |
| DRAM | Dynamic Random Access Memory |
| DSL | Digital Subscriber Line |
| DSLAM | Digital Subscriber Line Access Multiplexer (Module) |
| DSOM | Distributed System Object Model |
| DSP | Digital Signal Processor |
| DSR | Data Set Ready |
| DSTN | Double-layer Supertwist Nematic. (in Passive-matrix LCD Technology) |
| DSU | Data Service Unit |
| DSVD | Digital Simultaneous Voice And Data |
| DTD | Document Type Definition |
| DTE | Data Termination (Terminal) Equipment |
| DUN | Dial-Up Networking |
| DVD | Digital Versatile (Video) Disc |
| DVD+RW | Digital Versatile (Video) Disc + Read/Write |