| Acronym | Meaning |
 | CDF | Confined Detonating Fuse |
| CDF | Cool-Down Facility |
| CDF&TDS | Circuit Design |
| CDH | Constant Delta Height |
| CDI | Course Deviation Indicator |
| CDI | Course Deviation Indicator |
| CDM | Communications/Data Manager |
| CDMS | Command And Data Management Subsystem |
| CDMS | Command And Data Management System |
| CDN | CDRDiscrepancyNotice |
| CDNR | CDR Discrepancy Notice Record |
| CDP | CommandDataProcessor |
| CDPIS | Command Data Processing And Instrumentation System |
| CDQR | Critical Design And Qualification Review |
| CDR | Cleaning |
| CDR | Commander |
| CDR | Critical Design Review |
| CDRL | Contract Data Requirements List |
| CDRR | Contract Documentation Requirements Records |
| CDS | Central Data Subsystem |
| CDS | Central Data Subsystems (LPS) |
| CDS | Central Data System |
| CDS | Closeout DoorSystem |
| CDS | Collision Detector System |
| CDS | Control Data Corporation |
| CDS | Control Data System |
| CDSC | Communications Distribution And Switching Center |
| CDT | Central Daylight Time |
| CDT | Command Descriptor Table |
| CDT | Compressed DataTape |
| CDT | Configuration Data Table |
| CDT | Countdown Time |
| CDU | Computer Display Unit |
| CDU | Control And Display Unit |
| CDU | Coupling Display Unit |
| CDU | Coupling Data Unit |
| CDU | CRT Display Unit |
| CDW | Command Data Word |
| CDW | Computer DataWord |
| CE | Change Evaluation |
| CE | Civil Engineering |
| CE | Control Element |
| CE | Cost Element |
| CE | Current Expendable |
| CEA | Control Electronics Assembly (for MMU) |
| CEC | Control Encoder Coupler |
| CECP | Compatibility Engineering Change Proposal |
| CEDC | Cyclic Error Detection Code |
| CEI | Configuration End Item |
| CEI | Contract End Item |
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