| Acronym | Meaning |
 | NNI-I | NASA Standard Initiator-Type I (was SMSI) |
| NO | Nitric Oxide |
| NO | Normally Open |
| NO | Normally Open |
| NO | Not For Off -KSC Distribution |
| NO. | Number |
| NOAA | National Oceanic And Atmospheric Administration |
| NOC | Network Operation Control |
| NOC | Not Otherwise Coded |
| NOC | Notation Of Content |
| NOCC | Network Operations Control Center |
| NOCC | Network Operations Control Center (GSFC) |
| NOES | National Operational Environmental Satellite Serv. |
| NOISE | FigurNoise Figure |
| NOM | Network OutPut Multiplexer |
| NOM | Nominal |
| NOMINAL | PerNominal Percent Defective |
| NOR | Northrup Flight Strip |
| NOR | Normal |
| NORAD | North American Air Defense Command |
| NORDSAT | Scandinavian Countries Broadcast Satellite |
| NORM | Normal |
| NORMAL | LoadNormal Load Factor (g) |
| NORMAL | To ZNormal To Z-Axis |
| NOSE | To X-ANose To X-Axis |
| NOSE | To Y-ANose To Y-Axis |
| NOSE | To Z-ANose To Z-Axis |
| NOSL | Night/Day Optical Survey Of Thunderstorm Lightning |
| NOSP | Network Operations Support Plan |
| NOSS | National Oceanic Survey Satellite |
| NOT | ProvideNot Provided |
| NOT | RequireNot Required |
| NOT | SwitchaNot Switchable |
| NOZ | Nozzle |
| NP | Neptunium |
| NPC | NASA Publication Control |
| NPD | NASA PolicyDirective |
| NPDS | Nuclear Particle Detection Subsystem |
| NPL | Normal Power Level (see RPL) |
| NPN | NASA Part Number |
| NPRV | Nitrogen Pressure Relief Valve |
| NPS | NASA PlanningStudies |
| NPSH | Net Positive Suction Head |
| NPSP | Net Positive Static Pressure |
| NPU | Nitrogen Purge Unit |
| NPV | Nitrogen Pressure Valve |
| NR | Noise Rating |
| NR/T | Near Real-Time |
| NRC | Nonrecurring Costs |
| NRCC | National Research Council Of Canada |
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