| Acronym | Meaning |
 | NWS | Nose Wheel Steering |
| NWS | Nose-Wheel Steering |
| NWSA | Nose Wheel Steering Amplifier |
| NWSI | New World Services Inc. |
| NWT | Nonwatertight |
| NWW | Nose Wheel Well |
| NX | NOrmal To X-Axis |
| NY | Normal To Y-Axis |
| NZ | Normal Acceleration |
| NZB | Non Zero Binary |
| O | Engineering Order |
| O&C | Operation And Checkout |
| O&C | Operation(s) And Checkout (Building-was MSOB) |
| O&C | Operations And Checkout |
| O&C | Operations And Control |
| O&FS | Operations And Flight Support |
| O&M | Operation And Maintenance |
| O&P | Operations And Procedures |
| O&R | Overhaul And Repair |
| O-NAV | Onboard Navigation |
| O/B | Onboard |
| O/B | Operational Base |
| O/C | Operations Critical |
| O/D | On Dock |
| O/D | Outside Diameter |
| O/ET | Orbiter/External Tank |
| O/F | Oxidizet--to-Fuel Ratio |
| O/L | Overload |
| O/L-RC | Overload-Reverse Current |
| O/R | Outside Radius |
| O/R | Oxygen Relief |
| O/V | Overvoltage |
| O/V-U/V | Over Voltage/Under Voltage |
| O2 | Oxygen |
| OA | Office Of Applications (now OSTA) |
| OA | Operational Aft (DSC Or MOM) |
| OA | Operational Instrumentation MDM-Aft |
| OA | Orbital Assembly |
| OA | Output Axis |
| OA | Overall |
| OAA | Orbiter Access Arm |
| OAA | Orbiter Access Arm |
| OAA | Orbiter Alternate Airfield |
| OAC | Quality Assurance Chart |
| OAFD | Orbiter Air Flight Deck |
| OAFTO | Orbiter Atmospheric Flight Test Office |
| OAL | Overall Level |
| OALC | Ogden Air Logistics Center |
| OAMS | Orbital Attitude And Maneuvering System |
| OAS | Office Automation System |
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