| Acronym | Meaning |
 | ODB | Operational Data Book |
| ODC | Other Direct Costs |
| ODCDR | Orbiter Delta CDR |
| ODDS | Operational Data Delivery Services |
| ODES | Optical Discrimination Evaluation Study |
| ODF | Orbit Determination Facility |
| ODIN | Orbital Design Integration (System) |
| ODP | Operational Display Procedure |
| ODR | OutPut Data Redundancy |
| ODRAN | Operational Drawing Revision Advance Notice |
| ODU | Output Display Unit |
| OEAS | Orbital Emergency Arresting System |
| OECO | Outboard Engine CLjtoff |
| OEM | Original Equipment Manufacturer |
| OES | Orbiter Emergency Site |
| OESS | Orbiter/ET Separation Subsystem |
| OEX | Orbiter Experiments |
| OEX | Orbiter Experiments |
| OF | Operational FWD DSC Or MDM |
| OF | Operational Instrumentation MDM-FWD |
| OF | Orbital Flight |
| OF | Outside Face |
| OF | Oxidizer-to-Fuel Ratio |
| OF | Oxygen Fill |
| OFCC | Office Of Federal Contract Compliance |
| OFDS | Orbiter Flight Dynamics Simulator |
| OFDS | Oxygen Fluid Distribution System |
| OFI | Operational Flight Instrumentation |
| OFI | Operational Flight Instrumentation |
| OFK | Officiaf Flight Kit |
| OFK | OPtical Flight Kit |
| OFM | Original Equipment Manufacturer |
| OFP | Operational Flight Profile |
| OFP | Operational Flight Program |
| OFP | Orbiter Flight Program |
| OFS | Orbital (Orbiter) Flight System |
| OFS | OrbiterFunctionalSimulator |
| OFT | Orbital Flight Test |
| OFTDS | Orbital Flight Test Data System |
| OFTM | On-Orbit Flight Technique Meeting |
| OFTR | Orbital Flight Test Requirement |
| OG | Outer Gimbal (Roll) |
| OG | Oxygen Gage |
| OG | Zero Gravity |
| OGA | Outer Gimbal Angle |
| OGA | Outer Gimbal Axis |
| OGE | OperatingGroundEquipment |
| OGMT | Orbiter GreenwichMeanTime |
| OGS | Outer Glideslope |
| OGS | Oxygen Generation System |
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