| Acronym | Meaning |
 | OP | Operation |
| OP | Oxygen Purge |
| OPA | Operations Planning Analysis |
| OPB | Oxidizer Preburner |
| OPBOV | Oxidizer Preburner Oxidizer Valve |
| OPDAR | OPtical Detection And Ranging |
| OPE | Other Project Element |
| OPER | Operations |
| OPER | Operation |
| OPF | Orbiter Processing Facility |
| OPF | Orbiter Processing Facility |
| OPFC | Orbiter Preflight Checklist |
| OPGUID | OPtimum Guidance (Technique) |
| OPI | Orbiter Payload Interrogator |
| OPIDF | Operational Planning Identification File |
| OPIS | Orbiter Prime Item Specification |
| OPL | Open Problem List |
| OPL | Operational |
| OPLF | Orbiter Processing And Landing Facility |
| OPNS | Operational Phase |
| OPO | Orbiter Project(s) Office |
| OPOV | Oxidizer Preburner Oxidizer Valve |
| OPOV | Oxidizer Preburner Oxidizer Valve |
| OPP | Opportunity |
| OPP | OPPosite |
| OPPAR | Orbiter Project(s) Parts Authorization Request |
| OPPL | Orbiter Project Parts List |
| OPR | Office Of Primary Responsibility |
| OPR | Operations Planning Review |
| OPR | Operator |
| OPR | Orbiter/Payload Recorder |
| OPR | Oxygen Pressure Regulator |
| OPRV | Oxygen Pressure Relief Valve |
| OPS | Operational Sequence |
| OPS | Operations |
| OPS | Operations Sequence |
| OPS | Orbiter Project Schedules |
| OPS | Oxygen Purge System |
| OPSB | Orbiter Processing SuPport Building |
| OPSR | Operations Supervisor (GSTDN Site) |
| OPSS | Orbital Propellant Storage Subsystem |
| OPT | OPerational Pressure Transducer |
| OPT | Optics |
| OPT | Optimum |
| OPT | Option |
| OPTB | Operational Program Time Base |
| OPTB | Opposite |
| OR | OPerational Right |
| OR | Operations Requirement |
| OR | Operations Review |
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