| Acronym | Meaning |
 | CMTS | Computerized Maintenance Test System |
| CMV | Common Mode Voltage |
| CN | Change Notice |
| CNDS | Condensate |
| CNRL | Communications And Navigation Research Laboratory |
| CNSL | Console |
| CNTL | Control |
| CNTR | Counter |
| CNTRL | Control |
| CNTRL | Controller |
| CNWDI | Critical Nuclear Weapons Design Information |
| CO | Carbon Monoxide |
| CO | Cargo Operations (KSC Directorate) |
| CO | Change Order |
| CO | Contracting Officer |
| CO | Cutoff |
| CO2 | Carbon Dioxide |
| COA | Center Operations Area |
| COAS | Course Optical Alignment Sight |
| COAS | Crew(man) Optical Alignment Sight |
| COAS | Crewman Optical Alignment Sight |
| COAX | Coaxial |
| COB | Communications Office Building |
| COBE | Cosmic Background Explorer |
| COBOL | Common Business Oriented Language |
| COC | Close-Open-Close |
| COD | Center Operations Directorate (JSC) |
| COE | Corps Of Engineer |
| COFI | Checkout And Fault Isolation (on Board) |
| COFR | Certificate Of Flight Readiness |
| COFW | Certificate Of Flight Worthiness |
| COIM | Checkout Interpreter (Software) Module |
| COL | Checkout Language |
| COL | Coast Orbital Insertion |
| COLM | Column |
| COM | Common |
| COM | Computer Output Microfiche |
| COM-M | Common Mode |
| COMAS | Combined Orbital Maneuvering And Abort System |
| COMAT | Compatibility Of Materials |
| COMB | Combustion |
| COMEC | Communications Security |
| COMM | Communications |
| COMMAND | Computer Command Engineer |
| COMP | Compass |
| COMP | Compensate |
| COMP | Component |
| COMP | Computation Of Rendezvous Targeting |
| COMP | Computer |
| COMPEN | Compensator |
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