| Acronym | Meaning |
 | SCC | Standard Cubic Centimeters |
| SCCB | Site Configuration Control Board |
| SCCH | Standard Cubic Centimeters-per Hour |
| SCCM | Standard Cubic Centimeters Per Minute |
| SCD | Source Control Document |
| SCD | Source Control Drawing |
| SCD | Specification Control Document |
| SCD | Specification Control Drawing |
| SCDA | Safing |
| SCDP | Simulation Control Data Package |
| SCDR | Seller Critical Design Review |
| SCDR | Shuttle Critical Design Review |
| SCDR | Software Critical Design Review |
| SCDR | Subcontractor Critical Design Review |
| SCDU | Signal Conditioning And Display Unit |
| SCE | Signal Conditioning Equipment |
| SCEA | Signal Conditioning Electronics Assembly |
| SCF | Safing And DeServicing Facility |
| SCF | Satellite Control Facility |
| SCF | Satellite Control Facility |
| SCF | Sequenced Compatibility Firing |
| SCF | Spacecraft Control Facility |
| SCF | Standard Charge Factor |
| SCF | Standard Cubic Feet |
| SCF | Statistical Collection File |
| SCF | Sunnyvale Control Facility |
| SCFH | Standard Cubic Feet Per Hour |
| SCFM | Standard Cubic Feet Per Minute |
| SCFS | Standard Cubic Feed Per Second |
| SCGSS | Super Critical Gas Storage System |
| SCHED | Scheduled |
| SCHEM | Schematics |
| SCI | Switch Closure In |
| SCIM | Standard Cubic Inches Per Minute |
| SCIS | Standard Cubic Inches Per Second |
| SCIT | Standard Change Integration And Tracking |
| SCIU | Selector Control Interface Unit |
| SCIU | Spacecraft Interface Unit |
| SCL | Secondary Coolant Line |
| SCL | Secondary Coolant Loop |
| SCL | Specification Change Log |
| SCLM | Stability |
| SCM | Site Configuration Message |
| SCM | Subsystem Configuration Management |
| SCM | Subsystem Configuration Monitoring |
| SCM | System Control Module |
| SCM | System Control Module |
| SCMB | Development Configuration Management Board |
| SCMP | System Contractor Management Plan |
| SCN | Specification Change Notice |
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