| Acronym | Meaning |
 | SDCS | SAIL Data Communications SYstem |
| SDD | Shuttle Design Directive |
| SDD | Software DescriPtion Document |
| SDD | Software Design Document |
| SDD | System Design Document |
| SDE | Space Division Evaluator |
| SDF | Safing And Deservicing Facility |
| SDF | Single Degree Of Freedom |
| SDF | Software Development Facility |
| SDF | System Development Facility (Breadboard) |
| SDG | Supplier Documentation Group |
| SDH | Software Development Handbook |
| SDH | System Development Handbook |
| SDI | Selective Dissemination Of Information |
| SDIF | Software Development And Integration Facility |
| SDM | Shuttle Data Management |
| SDM | Subsystem Design Manuals |
| SDM | SYstem Definition Manual |
| SDN | Software Development Note |
| SDP | Shuttle Data Processor |
| SDP | Site Data Processor |
| SDP | Software Development Plan |
| SDP | Supplier Data Package |
| SDPC | Shuttle Data Processing Complex |
| SDPC | Shuttle Data Processing Complex |
| SDR | Software Design Requirements |
| SDR | Software Design Review |
| SDR | Space Division Regulation |
| SDR | Spacelab DisPosition Record (ESA) |
| SDR | System Design Review |
| SDRB | Software Design Review Board |
| SDRB | SUPPlier Documentation Review Board |
| SDRD | SuPplier Data Requirements Description |
| SDRD | SuPplier Documentation Review Data |
| SDRL | Supplier Data Requirements List |
| SDS | Shuttle Dynamic Simulation (Simulator) |
| SDS | Software Design Specification |
| SDS | Steering Damping System |
| SDSS | Space Division Shuttle Simulator |
| SDT | Scaling And Display Task |
| SDT | Shuttle Data Tape |
| SDT | Structural Dynamic Test |
| SDTA | Structural Dynamic Test Article |
| SDVF | Software DeveloPment And Verification Facilities |
| SE | Support EquiPment |
| SE&I | System Element |
| SE&I | SYstems Engineering And Integration |
| SE/FAC | Support Eq Uipm Ent/Facility |
| SEA | Scanning Electrostatic Analysis |
| SEA | Silicon Elastimeter Ablator |
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