| Acronym | Meaning |
 | SEACF | Support Equipment Assembly And Checkout Facility |
| SEADS | Shuttle Entry Air Data Sensor |
| SEADS | Shuttle Entry Air Data System |
| SEADS | Shuttle EntrY Air Data System (Subsystem) |
| SEAID | SuPport Equipment Abbreviated Items Description |
| SEAPG | Support Equipment Acquisition Planning Group |
| SEARCHS | Shuttle Engineer' |
| SEARCHS | Simulation |
| SEB | Scientific Equipment Bay |
| SEB | Source Evaluation Board |
| SEB | Support Equipment Building |
| SEB | SYstems Engineering Branch |
| SEC | Second |
| SEC | Secondary |
| SEC | Secondary |
| SEC | Sequential Events Controller |
| SEC | Source Evaluation Committee |
| SECO | Sustainer Engine Cutoff |
| SECS | Shuttle Events Control |
| SECS | Standard Cubic Centimeters Per Second |
| SEE | Special Purpose End Effector |
| SEE | Standard End Effector |
| SEE | Subsystem |
| SEG | Segment |
| SEI | SuPPort EquiPment Installation |
| SEI | SYstem Engineering Groundrule |
| SEICO | SuPPort EquiPment Installation And Checkout |
| SEICO | System Engineering Instrumentation |
| SEL | Select |
| SEM | Scanning Electron Microscope |
| SEM | Seller's Engineering Memo |
| SEM | Space Environment Monitoring |
| SEM | System Engineering Management |
| SEMS | Space Environment Monitor System |
| SEN | Sensor |
| SEND | Shared Equipment Need Date |
| SENS | Sensitivity |
| SEO | Special Engineering Order |
| SEOS | Synchronous Earth Observation Satellite |
| SEP | Separation |
| SEP | Source Evaluation Panel |
| SEP | SUPPort Equipment Package |
| SEPAP | Shuttle Electrical Power Analysis Program |
| SEPAR | Shuttle Electrical Power Analysis Report |
| SEPS | Solar Electric Propulsion System |
| SEQ | Sequence |
| SER | Serial |
| SERB | Shuttle Engineering Review Board |
| SERB | Systems Engineering Review Board |
| SERS | Shuttle Equipment Record System |
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