| Acronym | Meaning |
 | SERV | Service |
| SERVO | Servomechanism |
| SES | Shuttle Engineering Simulation |
| SES | SPecial Emphasis Study |
| SESC | Shuttle Events Sequential Control |
| SESL | Space Environmental Simulation Laboratory |
| SEUL | Support Equipment Utilization List |
| SF | Safe |
| SF | Directorate) |
| SF | Safe |
| SF | Safety Factor |
| SF | Scale Factor |
| SF | Selection Filter |
| SF | Signaling Frequency |
| SF | Sliding Filter |
| SF | Star Field |
| SF | Static Firing |
| SF | Subcontractor Furnished |
| SF-SOO | KSC Safety Operations Office |
| SFA | Sun Finder Assembly |
| SFACI | Software Flight Article Configuration Inspection |
| SFC | Selection Filter Control |
| SFC | Specific Fuel Consumption |
| SFCS | Survival Flight Control System |
| SFD | Crossfeed |
| SFDS | System Functional Design Specification |
| SFDT | Site Format Dump Tape |
| SFEX | Solar Flare X-ray Polarimeter |
| SFL | Secondary Freon Loop |
| SFME | Storable Fluid Management ExPeriment |
| SFO | Space Flight Operations |
| SFOM | Shuttle Flight Operations Manual |
| SFOP | Safety Operating Procedure (KSC) |
| SFP | Single Failure Point |
| SFP | Summary Flight Plan |
| SFPA | Single Failure Point Analysis |
| SFPPL | Short Form Provisioning Parts List |
| SFPS | Single Failure Point Summary |
| SFS | Shuttle Flight Status |
| SFSS | Satellite Field Service Station |
| SFT | Shaft |
| SFT | Simulated Flight Test |
| SFT | Static Firing Test |
| SFTA | Structural Fatigue Test Article |
| SFTF | Static Firing Test Facility |
| SFTWE | Software |
| SFU | Standard Firing Unit |
| SFW | Software |
| SFWE(M) | Static Feed Water Electrolysis (Module) |
| SG | Gnal Generator |
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