| Acronym | Meaning |
 | SG | LSSpace Ground Link Station |
| SGC | Abilized Ground Cloud |
| SGLS | Space-ground Link System |
| SGLSY | Space Ground Link SYstem |
| SGMT | Simulated Greenwich Mean Time |
| SGOS | Shuttle Ground Operations Simulation (Simulator) |
| SGP | Single Ground Point |
| SGS | Steep Glide Slope |
| SGSC | Strain Gage Signal Conditioner |
| SH | LDShield |
| SH2 | Supercritical Hydrogen |
| SHA | Sidereal Hour Angle |
| SHA | System Hazard Analysis |
| SHAG | Simplified High Accuracy Guidance (Honeywell) |
| SHDN | Shutdown |
| SHE | SuPercritical Helium |
| SHERB | Sandia Human Error Rate Bank |
| SHF | Super High Frequency |
| SHLB | Simulation Hardware Load Boxes |
| SHLDR | Shoulder |
| SHORAN | Short Range Navigation |
| SHP | Shaft HorsePower |
| SHRD | Shroud |
| SHRD | Supplemental Heat Rejection Devices |
| SHS | Simulation Hardware System |
| SHTR | Shutter |
| SHUTDN | Shutdown |
| SI | Center Support Operations (KSC Directorate) |
| SI | International System Of Units (ISU Preferred) |
| SI | Scientific Instrument |
| SI | Solar Inertial |
| SIA | Shuttle Induced Atmosphere |
| SIA | Software Impact Assessment |
| SIA | Solar Inertial Attitude |
| SID | Shuttle Integration Device |
| SID | Simulator Interface Devices |
| SID | Standard Interface Document |
| SID | System Interface Document |
| SIE | Shuttle Interface Equipment Services |
| SIES | Supervision |
| SIG | Signal |
| SIG | CONDR Signal Conditioner |
| SIG | GEN Signal Generator |
| SIL | Silver |
| SIL | Sound Interference Level |
| SIL | Systems Integration Laboratory |
| SILTS | Shuttle Infrared Leeside Temperature Sensing |
| SILTS | Shuttle Infrared Leeside Temperature Sensing |
| SIM | Simulate |
| SIM | Scientific Instrumentation Module |
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