| Acronym | Meaning |
| SMAB | Solid Motor Assembly Building |
| SMAG | Star Magnitude |
| SMART | Shuttle Meeting Action - Item Review Tracking |
| SMB | Space Meteorology Branch |
| SMC | Scientific ManPower Commission |
| SMCC | Shuttle Mission Control Center |
| SMCH | Standard Mixed Cargo Harness |
| SMCS | Separation Monitor And Control System |
| SMCU | Separation Monitoring Control Unit |
| SMD | Spacelab Mission DeveloPment |
| SMD | Special Measuring Device |
| SMD | Special Measuring Service |
| SMDC | Shielded Mild Detonating Cord |
| SMEAR | Span/Mission Evaluation Action Request |
| SMG | SPaceflight Meteorology Group |
| SMG | Superconduction Magnetic Energy Storage |
| SMIR | Shuttle Multispectral Infrared Radiometer |
| SML | Structure Mold Line |
| SMM | Solar Maximum Mission |
| SMM | Subsystem Measurement Management |
| SMMD | Specimen Mass Measurement Device |
| SMOC | Simulation Mission Operation Computer |
| SMP | Software Management Plan |
| SMPM | Structural Materials Property Manual |
| SMPTRB | Shuttle Main Propulsion Test Requirement Board |
| SMQ | Structure Module Qualification Test |
| SMR | Source, Maintenance, And Recoverability |
| SMRD | Spin Motor Rotational Detector |
| SMRD | Spin Motor Run Discrete |
| SMRM | Solar Maximum Repair Mission |
| SMS | Separation Mechanism SubsYstem |
| SMS | Shuttle Mission Simulator |
| SMS | Shuttle Mission Simulator |
| SMS | Solar Maximum Satellite |
| SMS | Synchronous Meteorological Satellite |
| SMSI | Standard Manned Space Flight Initiator |
| SMT | Selective Message Transaction |
| SMTAS | Shuttle Model Test And Analysis System |
| SMU | SOft Mockup |
| SMU | Speaker/microphone Unit |
| SMVP | Shuttle Master Verification Plan |
| SMVRD | Shuttle Master Verification Requirements Document |
| SMW | Standard Materials Worksheet |
| SNF | SYstem Noise Figure |
| SNR | Signal-to-Noise Ratio |
| SNSO | Space Nuclear SYstems Office |
| SNSR | Sensor |
| SO | SuPport Operations (KSC Dir.) |
| SO | FT Square Feet |
| SO2 | Sulphur Dioxide |