| Acronym | Meaning |
| SRD | SYstems Requirements Document |
| SRDH | Subsystems Requirement Definition Handbook |
| SRDH | System Requirements Definition Handbook |
| SRE | STDN Ranging Equipment |
| SRF | Shuttle Refurbishment Facility |
| SRH | Subsystems Requirements Handbook |
| SRM | Solid Rocket Motor |
| SRM | Solid Rocket Motor |
| SRM | SPecification Requirements Manual |
| SRM | Standard Reference Material |
| SRMC | Stimulus/Response Measurements Catalog |
| SRN | Software Release Notice |
| SRO | Supervisor Range Operations |
| SRPA | Spherical Retarding Potential Analyzer |
| SRR | Shuttle Requirements Review |
| SRR | Site Readiness Review |
| SRR | Software Requirements Review |
| SRR | System Requirements Review |
| SRS | Simulated Remote Station |
| SRS | Software Requirements Specification |
| SRS | Specification Revision Sheet |
| SRS | Support Requirements System |
| SRSF | SRB Receiving And Subassembly Facility |
| SRSF | SRB Refurbishment And Subassembly Facility |
| SRSR | Schedule And Resources Status Report |
| SRSS | Shuttle Range Safety System |
| SRT | Shuttle Requirements Traceability |
| SRT | Special Rated Thrust |
| SRT | Specification Requirements Table |
| SRT | Station Readiness Test |
| SRT | Supporting Research And Technology |
| SRU | Shop Replacement Unit |
| SRU | ShOP-Replaceable Unit |
| SRU | Space Replaceable Units |
| SRVL | Survival |
| SS | Shuttle System |
| SS | Single Sideband |
| SS | Single String |
| SS | Space Shuttle |
| SS | Space Station |
| SS | Station Set |
| SS | Subsystem |
| SS | Sunset |
| SS | System Software |
| SS | System Specification |
| SS | System Summary |
| SS&A | Space Systems And Applications |
| SSA | S-Band Single Access |
| SSA | Shuttle Simulation Aircraft |
| SSA | Space Suit Assembly |