| Acronym | Meaning |
 | SSA | 1/0 GCOS Program Element Name |
| SSAT | Shuttle Service And Access Tower |
| SSAT | SPace Shuttle Access Tower (now FSS) |
| SSB | Single Sideband |
| SSB | Source Selection Board |
| SSBC | Summary Sheet Bar Chart |
| SSC | Shuttle System Contractor |
| SSC | Single-Stage Command |
| SSC | Solid-Solution Cermet |
| SSC | Subsystem Computer |
| SSC | Subsystem Sequence Controller |
| SSC | L Shuttle System Commonality List |
| SSCA | Surface Sampler Control Assembly |
| SSCC | Support Services Control Center |
| SSCHS | Space Shuttle Cargo Handling System |
| SSCP | Small Self-Contained Payloads |
| SSCSP | Space Shuttle Crew Safety Panel |
| SSD | Spacecraft Software Division |
| SSD | System Summary Display |
| SSDD | Software System Design Document |
| SSDH | Subsystem Data Handbook |
| SSDS | Space Station Data System |
| SSE | Space Shuttle Engines |
| SSE | Subsystem Element |
| SSE | SubsYstem Support Equipment |
| SSEOS | Space Shuttle Engineering And Operations Support |
| SSF | SRB Storage Facility |
| SSFGSS | Space Shuttle Flight And Ground System Specification |
| SSFL | Santa Susana Field Laboratory |
| SSFS | Space Shuttle Functional Simulator |
| SSHB | Station Set Handbook |
| SSI | Significant Structural Item |
| SSIBD | Shuttle System Interface Block Diagram |
| SSID | Shuttle Stowage Installation Drawing |
| SSIP | Systems Software Interface Processing |
| SSIS | Space Station Information System |
| SSITP | Shuttle System Integrated Test Plan |
| SSL | System Software Loader |
| SSM | SPacecraft Systems Monitor |
| SSM | Subsystem Manager |
| SSM | Support System Module |
| SSM | Systems Support Module |
| SSM | BSpace Shuttle Maintenance Baseline |
| SSM | ESpace Shuttle Main Engine |
| SSM | EC Space Shuttle Main Engine Controller |
| SSME | Space Shuttle Main Engine |
| SSMECA | Space Shuttle Main Engine Controller Assembly |
| SSMECA | SSM E Controller Assembly |
| SSO | Safety Signification Operation |
| SSO | Source Selection Official |
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