| Acronym | Meaning |
 | SSO | Space Shuttle Orbiter |
| SSO | Subsystem Operation (in Spacelab) |
| SSO | SuPport System For OEX |
| SSOP | Space Systems Operating Procedure(s) |
| SSP | Small Sortie Payload |
| SSP | Space Shuttle Program |
| SSP | Standard Switch Panel |
| SSPC | Spacelab Stored Program Command |
| SSPD | Shuttle System Payload Data |
| SSPD | Shuttle System Payload Definition (Study) |
| SSPD | Shuttle System Payload Description |
| SSPDA | Space Shuttle Payload Data Activity |
| SSPDB | Subsystem Power Distribution Box |
| SSPDS | Space Shuttle Payload Data Study |
| SSPGSE | Space Shuttle Program Ground Support Equipment |
| SSPM | Space Shuttle Program Manager |
| SSPO | Space Shuttle Program Office |
| SSPP | SYstem Safety Program Plan |
| SSPPSG | Space Shuttle Payload Planning Steering Group |
| SSPRO | Space Shuttle Program Resident Office |
| SSPS | Space Shuttle Program Schedule |
| SSPTF | Santa Susana Propulsion Test Facility (see SSFL) |
| SSR | Shop Support Request |
| SSR | Staff SuPport Room |
| SSR | Station Set Requirement |
| SSR | System Requirements Review |
| SSRD | Station Set Requirements Documents |
| SSRN | System Software Reference Number |
| SSRR | Station Set Requirements Review |
| SSS | Sound Suppression System |
| SSS | Space ShuttleSystem |
| SSS | Stage Separation Subsystem |
| SSS | Station Set Specification |
| SSS | Subsystem Segment |
| SSSS | Space Shuttle System Specification |
| SST | Single System Trainer |
| SST | SPacecraft Systems Test |
| SST | Structural Static Test |
| SST | Subsystem Terminal On Spacelab |
| SSTC | Space Shuttle Test Conductor |
| SSUS | Spinning Solid Upper Stage |
| SSUS-A | SSUS For Atlas-Centaur Class Spacecraft |
| SSUS-D | SSUS For Delta Class Spacecraft |
| SSUSP | Spinning Solid Upper Stage Project |
| SSV | Space Shuttle Vehicle |
| ST | Self Test |
| ST | Sequential Timer |
| ST | SimPlification Task |
| ST | SPace Telescope |
| ST | Spacelab Technology |
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