| Acronym | Meaning |
 | STM | Support Test Manager |
| STN | Software Trouble Note |
| STO | Stow |
| STOCC | Space Telescope Operations Control Center |
| STP | Self-Test Program |
| STP | Shuttle Technology Panel |
| STP | Space Technology Payload |
| STP | Space Test Program |
| STP | Subsystem Test Plan |
| STPH | Static Phase Error |
| STR | Structure |
| STR | System Test Review |
| STR | LStructural |
| STRB | Strobe |
| STRCH | Stretch |
| STRFLD | Star Field |
| STRG | Steering |
| STRG | String |
| STRUC | Structure |
| STRUCT | Structure |
| STS | Shuttle Test Station |
| STS | Space Transportation System |
| STS | Space Transportation System |
| STS | Structural Transition Section |
| STS | RSystem Test Summary Report |
| STSG | Shuttle Test Group |
| STSOPO | Off Ice (JSC) |
| STSOPO | Shuttle Transportation Systems Operations Program |
| STT | Spacelab Transfer Tunnel |
| STU | Special Test Unit |
| STU | Star Tracker Unit |
| SU | Support Unit |
| SUB | Substitute |
| SUBJ | Subject |
| SUM | Summary |
| SUMC | Space Ultrareliable Modular Computer |
| SUMM | Summary |
| SUMS | Shuttle Upper Atmosphere Mass Spectrometer |
| SUMS | Shuttle Upper-Atmosphere Mass Spectrometer |
| SUP | Supply |
| SUP | Support |
| SUPCRIT | Supercritical |
| SUPPR | Suppression |
| SUPSALV | Supervisor Of Salvage (U.S. Navy) |
| SUPT | Support |
| SUPV | Supervisor |
| SURE | Shuttle Users Review And Evaluation |
| SURF | Surface |
| SURS | Standard Umbilical Retraction System |
| SUSIM | Solar Ultraviolet Spectral Irradiance Monitor |
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