| Acronym | Meaning |
| ES | Experiment Segment |
| ESA | Engineering SuPPly Area |
| ESA | Engineering SuPPort Assembly |
| ESA | European Space Agency |
| ESA | European Space Agency |
| ESA | ExPlosive Safe Area |
| ESA | Explosive Safe Area (KSC) |
| ESB | Essential Switching Box |
| ESC | Escape |
| ESCA | Electron Spectroscopy For Chemical Analysis |
| ESCU | Extended Service And Cooling Umbilical |
| ESD | Emergency Shutdown |
| ESD | Experiment Systems Division |
| ESDAC | European Space Data Center (Darmstadt |
| ESDU | Event Storage And Distribution Unit |
| ESE | Electrical Support Equipment |
| ESE | Electronic SuPport Equipment |
| ESE | EVA Support Equipment |
| ESF | Explosive Safe Facility |
| ESI | Electrical System Integration |
| ESMC | Eastern Space And Missile Center (formerly AFETR) |
| ESMC | ETR |
| ESO | Event Sequence Override |
| ESOC | European Space Operations Center |
| ESOW | Engineering Statement Of Work |
| ESP | Electroshock Protection |
| ESP | Engine Service Platforms |
| ESP | Experiment Sensing Platform |
| ESPS | Experiment Segment Pallet Simulator |
| ESR | Effective Sunrise |
| ESR | Engineering Support Request |
| ESRIN | European Space Research Institute |
| ESRO | European Space Research Organization |
| ESRO | European Space Research Organization |
| ESS | Effective Sunset |
| ESS | Environmental Support System |
| ESS | Equipment Support Section |
| ESS | Essential |
| ESS | Essential |
| ESS | Experiment Subsystem Simulator |
| ESSA | Environmental Sciences Services Administration |
| EST | Eastern Standard Time |
| EST | Estimate(d) |
| ESTA | Electronic System Test Equipment |
| ESTA | Escape System Test Article |
| ESTEC | European Space Research And Technology Center |
| ESTEC | European Space Technology Center |
| ESTL | Electronic Systems Test Laboratory |
| ESV | Emergency Shutoff Valve |
| ESVS | Escape Suit Ventilation System |