| Acronym | Meaning |
| ESVS | Escape Suit Ventilation System |
| ESVS | Escape System Ventilation System |
| ESW | Engine Status Word |
| ET | Edge Thickness |
| ET | Elapsed Time |
| ET | Elevated Temperature |
| ET | Event Timer |
| ET | External Tank |
| ET | External Tank |
| ET-SEP | External Tank Separation |
| ETA | Environmental Test Article |
| ETA | Estimated Time Of Arrival |
| ETA | Estimated Time To Acquisition |
| ETA | Explosive Transfer Assembly |
| ETA | External Tank Attachment |
| ETB | Equipment Transfer Bag |
| ETC | Greenbelt |
| ETC | Earth Terrain Camera |
| ETC | Estimate To Completion |
| ETCO | Equipment Transfer/Change Order |
| ETD | Electrical Terminal Distributor |
| ETD | Estimated Turnover Date |
| ETD | External Tank Door |
| ETE | End-to-End |
| ETI | Elapsed Time Indicator |
| ETLOW | External Tank Lift-Off Weight |
| ETM | ElaPsed Time Meter |
| ETP | Equipment Test Plan |
| ETR | Eastern Test Range |
| ETR | Eastern Test Range (ESME Preferred) |
| ETROD | Eastern Test Range Operations Directive |
| ETS | Electrical Test Set |
| ETS | Energy Transfer System |
| ETS | External Tank System (Subsystem) |
| ETSS | External Tank Separation Subsystem |
| ETVA | External Tank Vent Arm |
| EU | Electronic Unit |
| EU | Engineering Units |
| EU | Experimental Unit |
| EUROCOMSATE | European Consortium Communications Satellite |
| EUV | Extreme Ultraviolet |
| EUVE | Extreme Ultraviolet Explorer |
| EV | Electron Volts |
| EV | Expendable Vehicles |
| EV | Extravehicular |
| EVA | Earned Value Analysis |
| EVA | Extravehicular Activity |
| EVA | Extravehicular Activity |
| EVAL | Evaluate |
| EVAL | Earth Viewing Applications Laboratory |