| Acronym | Meaning |
 | LB | Launch Bus |
| LB | Load Bank |
| LB | Low Bay |
| LB | Lower Brace |
| LB | Pound |
| LBDT | Low Bay Dolly Tug |
| LBK | Left Bank |
| LBL | Left Buttock Line |
| LBM | Load Buffer Memory |
| LBNPD | Lower Body Negative Pressure Device |
| LBR | Low Bit Rate |
| LC | Incremental Cost |
| LC | Information Center |
| LC | Initial Condition |
| LC | Integrated Circuit |
| LC | Intercom (Orbiter To Ground Via Hardline) |
| LC | Intercommunications |
| LC | Intercomputer |
| LC | Interim Change |
| LC | Internal Combustion |
| LC | Ion Chamber |
| LC | LaunchCountdown |
| LC | Launch Complex |
| LC | Launch Critical |
| LC | Left Center |
| LCA | Launch Control Amplifier |
| LCA | Load Controller (Control) Assembly |
| LCA | Load Controller Assembly |
| LCB | Least Common Bit |
| LCC | Launch Commit Criteria |
| LCC | Launch Control Center |
| LCC | Launch Control Center (KSC) |
| LCC | Life Cycle Cost |
| LCCD | Launch Commit Criteria Document |
| LCD | LaunchCountdown |
| LCF | LowCycle Fatigue |
| LCG | Liquid Cooled Garment |
| LCG | Liquid-cooled Garment |
| LCH | Latch |
| LCH | LatLaunch |
| LCHTF | LowCYcle High Temperature Fatigue |
| LCL | Local |
| LCM | Least Common Multiple |
| LCMS | LowCost Modular Spacecraft |
| LCO | MMCUniform Central Number |
| LCOM | Logic Control OutPut Module |
| LCR | LowCross Range |
| LCS | Instrumentation Control SYstem |
| LCS | LauList Of Command Signals |
| LCS | Launch Control System |
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