| Acronym | Meaning |
 | LCT | Launch Countdown |
| LCU | Inertial Components Temperature Controller |
| LCU | Line Coupling Unit |
| LCUG | Liquid Cooling Under Garment |
| LCVG | Liquid Cooling And Ventilation Garment |
| LCVG | Liquid Cooling And Ventilation Garment |
| LD | Lateral Direction |
| LD | LatLoading Dock |
| LDB | LauLogistics Data Bank |
| LDB | Launch Data Bus |
| LDEC | Lunar Docking Events Controller |
| LDEF | Long Duration ExPosure Facility |
| LDG | Landing |
| LDIU | Launch Data Interface Unit |
| LDMK | Landmark |
| LDR | Low Data Rate |
| LDR | LowData Rate |
| LDS | LanLanding |
| LDS | Landing/Deceleration Subsystem |
| LDS | LanLoads |
| LDT | Linear Displacement Transducer |
| LE | LauLeading Edge |
| LE | Launch Escape |
| LEA | Logistics Engineering Analysis (Analyses) |
| LEB | Lower Equipment Bay |
| LEC | Lockheed Electronics Company |
| LED | Light Emitting Diode |
| LED | Light-emitting Diode |
| LEH | Launch/Entry Helmet |
| LEM | Laboratory Environment Model |
| LEM | Launch Escape Monitor |
| LEO | Low Earth Orbit |
| LER | Long Eye Relief (Optics) |
| LERC | Lewis Research Center (Cleveland |
| LES | Launch Equipment Shop |
| LES | Launch Escape Subsystem |
| LESS | Leading Edge Structure Subsystem |
| LESS | Leading Edge Structure Subsystem |
| LESS | Leading Edge Subsystem |
| LETF | Launch Equipment Test Facility |
| LETF | Launch Equipment Test Facility (KSC) |
| LF | Launch Facility |
| LF | Launch Forward |
| LF | Left Forward |
| LF | Load Factor |
| LF | Low Frequency |
| LFAF | Low Frequency Accelerometer Flutter |
| LFAM | Low Frequency Accelerometer Modes |
| LFAP | Low Frequency Accelerometer Pogo |
| LFC | Large Format Camera |
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