| Acronym | Meaning |
| CCN | Contract Change Notice |
| CCOH | Corrosive Contaminants |
| CCP | Center Console Panel |
| CCP | Charge Capacitance Probe |
| CCP | Commercial Change Proposal |
| CCP | ComPuter Control Panel |
| CCP | Configuration Change Point |
| CCP | Configuration Control Panel |
| CCP | Configuration Control Phase |
| CCP | Contract Change Proposal |
| CCP | Cost Control Program |
| CCR | Contractor Change Request |
| CCR | Control Center Rack |
| CCRA | Cape Canaveral Reference Atmosphere |
| CCRF | Consolidated Communication Recording Facility |
| CCS | Central Control Section |
| CCS | Central Control Station |
| CCS | Command And Communication System |
| CCS | Command And Control Subsystem |
| CCS | Complex Control Set |
| CCS | Computer Core Segment |
| CCS | Console Communication System |
| CCS | Contamination Control System |
| CCT | Computer Compatible Tape |
| CCTV | Closed Circuit Television |
| CCTV | Closed-circuit Television |
| CCU | Camera Control Unit |
| CCU | Central Control Unit |
| CCU | Communications Carrier Umbilical |
| CCU | Crew Communications Unit |
| CCU | Crewman Communications Umbilical |
| CCV | Chamber Coolant Valve |
| CCVA | Chamber Coolant Valve Actuator |
| CCW | Counterclockwise |
| CD | Candella (Luminous Intensity) |
| CD | Center Director (KSC Directorate) |
| CD | Coefficient Of Drag |
| CD | Command Decoder MDM |
| CDA | Command And Data Acquisition |
| CDA | Critical Design Audit |
| CDB | Central Data Buffer |
| CDB | Command Data Base |
| CDBFR | Common Data Buffer |
| CDC | Confined Detonating Cord |
| CDC | Countdown Clock |
| CDDT | Countdown Demonstration Test |
| CDF | Cable Distribution Frame |
| CDF | Central Data Facility |
| CDF | Circuit Design Fabrication |
| CDF | Confined Detonating Fuse |