| Acronym | Meaning |
| REHI | Hello Again |
| RESQ | Rescue |
| RFC | Request For Comment |
| RFD | Request For Discussion |
| RL | Real Life - I.e. When Not Chatting |
| ROFL | Roll On Floor Laughing |
| ROR | Raffing Out Roud (from ScoobyDoo = "laughing Out Loud") |
| ROTFL | Rolling On The Floor Laughing |
| ROTFLMAO | Rolling On The Floor Laughing My Ass Off |
| ROTFLMBO | Rolling On The Floor Laughing My Butt Off |
| RPG | Role-playing Games |
| RSN | Real Soon Now |
| RT | Real Time |
| RTFM | Read The F*cking Manual |
| RTM | Read The Manual |
| RUOK | Are You OK? |
| RYO | Roll Your Own |
| S | Smile |
| S2R | Send To Receive |
| S4L | Spam For Life |
| SB | Smiles Back |
| SCNR | Sorry, Could Not Resist |
| SEG | S**t-eating Grin |
| SETE | Smiling Ear To Ear |
| SHCOON | Shoot Hot Coffee Out Of Nose |
| SHID | Slaps Head In Disgust |
| SIL | Sister In Law |
| SITD | Still In The Dark |
| SLY | Still Love You |
| SMEM | Send Me An Email |
| SMIM | Send Me An Instant Message |
| SNAFU | Situation Normal, All F*cked Up |
| SO | Significant Other (boyfriend, Girlfriend, Wife, Husband, Partner, Spouse |
| SOHF | Sense Of Humour Failure |
| SOL | Smiling Out Loud |
| SOL | Stuff Outta Luck |
| SOMY | Sick Of Me Yet? |
| SOS | Same Old Stuff |
| SOT | Short On Time |
| SOTMG | Short On Time Must Go |
| SSDD | Same Stuff Different Day |
| STFU | Shut The F*ck Up |
| STFW | Search The F*cking Web |
| STR8 | Straight |
| STW | Search The Web |
| SU | Shut Up |
| SUAKM | Shut Up And Kiss Me |
| SUP | What's Up |
| SWAG | Stupid Wild-a** Guess |
| SWAK | Sealed With A Kiss |